Adverse drug reactions related to treatment of drug-susceptible tuberculosis in Brazil: a prospective cohort study

dc.creatorSant´Anna, Flávia M.
dc.creatorPereira, Mariana Araújo
dc.creatorSchmaltz, Carolina A. S.
dc.creatorArriaga, María B.
dc.creatorOliveira, Raquel V. C. de
dc.creatorAndrade, Bruno B.
dc.creatorRolla, Valeria C.
dc.date2022-03-07T16:59:33Z
dc.date2022-03-07T16:59:33Z
dc.date2022
dc.date.accessioned2023-09-26T20:57:02Z
dc.date.available2023-09-26T20:57:02Z
dc.identifierSANT´ANNA, Flávia M. et al. Adverse drug reactions related to treatment of drug-susceptible tuberculosis in Brazil: a prospective cohort study. Frontiers in Tropical Diseases, v. 2, p. 1-11, Jan. 2022.
dc.identifier2673-7515
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51593
dc.identifier10.3389/fitd.2021.748310
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866685
dc.descriptionPrograma Brasileiro de DST-AIDS e Hepatites Virais. UNODC. Laboratório de Pesquisa Clínica em Micobactérias do INI, FIOCRUZ. Intramural Research Programa da Fundação Oswaldo Cruz. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Ńivel Superior (CAPES)
dc.descriptionStandard anti-tuberculosis treatment is highly effective, but a great challenge is the management of adverse drug reactions (ADR). Our study aimed to characterize ADR according to type, severity and time of occurrence. A prospective tuberculosis (TB) cohort has been followed, from 2010 to 2016, at a reference center in Rio de Janeiro, Brazil. Clinical and laboratory tests information were collected in all visits. ADR were described according to the affected organ/system, classified as clinical and/or laboratory, early (first 2 months) or late. ADR’s causality and intensity were assessed. In our study 552 patients were included, 78.8% presented at least one ADR, 34% were people living with HIV (PLHIV). Most ADR were clinical (53%), early (82.5%), mild/moderate (88.7%) events and of “metabolic annutritional disorders” category. There were no significant differences in type, severity or causality between “early” and “late” groups. However, “early” group presented a higher frequency of “metabolic and nutritional disorders” (27.8%) and “gastrointestinal system disorders” (23.5%), while “skin and appendages disorders” were more frequent in the “late” group. ADR are frequent and occur at any time during treatment, although the majority are early and grade and not severe.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectTuberculose
dc.subjectToxicidade
dc.subjectAntituberculosos
dc.subjectTuberculosis
dc.subjectToxicity
dc.subjectAntitubercular Agents
dc.subjectTuberculosis
dc.subjectToxicidad
dc.subjectAntituberculosos
dc.subjectTuberculose
dc.subjectToxicité
dc.subjectAntituberculeux
dc.titleAdverse drug reactions related to treatment of drug-susceptible tuberculosis in Brazil: a prospective cohort study
dc.typeArticle


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