Clinicopathological aspects and proviral load of adulthood infective dermatitis associated with HTLV-1: Comparison between juvenile and adulthood forms

dc.creatorSouza, Lucca Santos
dc.creatorSilva, Thadeu Santos
dc.creatorOliveira, Maria de Fátima Paim de
dc.creatorFarre, Maria Lourdes
dc.creatorBittencourt, Achilea Candida Lisboa
dc.date2020-06-29T14:35:18Z
dc.date2020-06-29T14:35:18Z
dc.date2020
dc.date.accessioned2023-09-26T20:56:51Z
dc.date.available2023-09-26T20:56:51Z
dc.identifierSOUZA, Lucca Santos et al. aspects and proviral load of adulthood infective dermatitis associated with HTLV-1: Comparison between juvenile and adulthood forms. PLOS Neglected Tropical Diseases, abr. 2020.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41946
dc.identifier10.1371/journal.pntd.0008241
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866633
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (http://www.cnpq.br/), grant number 409985/2016-3, received by AL and by the Fundação de Amparo a Pesquisa do Estado da Bahia (http://www.fapesb.ba.gov.br), grant number 4345/2012. This project has also received fundingfrom the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska Marie Curie grant agreement num 799850 (LF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.descriptionInfective dermatitis associated with human T-cell lymphotropic virus type-1 (HTLV-1), (IDH), is a chronic eczema occurring in HTLV-1 infected children. Rare cases of adulthood IDH have been reported and no study until now aimed to compare juvenile and adulthood IDH. Methodology/Principal findings Twelve cases of adulthood IDH followed for a mean time of 7.5 years were analyzed according to clinicopathological and molecular aspects, comparing them to juvenile IDH cases. Diagnosis was based on the modified major criteria used for juvenile IDH. Proviral load (PVL) assessment was performed by real-time PCR technique. Adulthood IDH presented similar clinicopathological and molecular aspects compared to juvenile IDH. The morphology of lesions and areas of involvement were similar, except for the involvement of the ankles and inframammary folds in the adulthood form. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) occurred in six adulthood IDH patients, with almost equal frequency. However, at least in two patients, HAM/TSP appeared prior to IDH, differently from what was observed in juvenile IDH. Conclusions/Significance Adulthood IDH is similar to juvenile IDH according to clinicopathological aspects and PVL levels. Therefore, the same modified major diagnostic criteria for juvenile IDH can be applied to both forms.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectDermatite
dc.subjectHTLV-1
dc.subjectVírus Linfotrópico T Tipo 1 Humano
dc.subjectCrianças
dc.subjectDermatitis
dc.subjectHTLV-1
dc.subjectHuman T-lymphotropic virus 1
dc.subjectChildren
dc.titleClinicopathological aspects and proviral load of adulthood infective dermatitis associated with HTLV-1: Comparison between juvenile and adulthood forms
dc.typeArticle


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