Significance of schistosomal granuloma modulation

dc.creatorSilva, Luciana Menezes da
dc.creatorFernandes, André L. M
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorOliveira, Irismar Reis de
dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-03T21:15:58Z
dc.date2012-10-03T21:15:58Z
dc.date2000
dc.date.accessioned2023-09-26T20:56:36Z
dc.date.available2023-09-26T20:56:36Z
dc.identifierSILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5639
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866562
dc.descriptionHepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenon, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the liver, participation of local factors, hitherto little considered, seems crucial. Components of the extracellular matrix of periovular granulomas of the mouse were particularly studied in three different organs (liver, lung and intestine) and during three periods of infection time (acute, intermediate and chronic) by means of histological, biochemical and immunofluorescence techniques, while quantitative data were evaluated by computerized morphometry, in order to investigate participation of local factors in granuloma modulation. Results confirmed modulation as a exclusively hepatic phenomenon, since pulmonary and intestinal granulomas, formed around mature eggs, did not change size and appearance with time. The matricial components which were investigated (Type I, III and IV collagens, fibronectin, laminin, proteoglycans and elastin) were found in all granulomas and in all organs examined. However, their presence was much more prominent in the liver. Elastin was only found in hepatic granulomas of chronic infection. The large amount of extracellular matrix components found in hepatic granulomas was the main change responsible for the morphological aspects of modulation. Therefore, the peculiar environment of the liver ultimately determines the changes identified in schistosomal granuloma as "modulation".
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectModulation
dc.subjectGranuloma
dc.subjectShistosomiasis
dc.subjectExtracellular matrix
dc.subjectGranuloma/patologia
dc.subjectEnteropatias Parasitárias/patologia
dc.subjectHepatopatias Parasitárias/patologia
dc.subjectPneumopatias Parasitárias/patologia
dc.subjectSchistosoma mansoni/imunologia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectAnimais
dc.subjectMatriz Extracelular
dc.subjectFeminino
dc.subjectGranuloma/imunologia
dc.subjectGranuloma/parasitologia
dc.subjectEnteropatias Parasitárias/imunologia
dc.subjectEnteropatias Parasitárias/parasitologia
dc.subjectHepatopatias Parasitárias/imunologia
dc.subjectHepatopatias Parasitárias/parasitologia
dc.subjectPneumopatias Parasitárias/imunologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectContagem de Ovos de Parasitas
dc.subjectEsquistossomose mansoni/imunologia
dc.subjectEsquistossomose mansoni/parasitologia
dc.subjectFatores de Tempo
dc.titleSignificance of schistosomal granuloma modulation
dc.typeArticle


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