Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients

dc.creatorAraujo, Jacqueline
dc.creatorSegat, Ludovica
dc.creatorGuimarães, Rafael L.
dc.creatorBrandão, Lucas A. C.
dc.creatorSouza, Paulo E. R.
dc.creatorSantos, Sérgio
dc.creatorSoares, Thereza S.
dc.creatorFalcão, Elcy A.
dc.creatorRodrigues, Fernanda
dc.creatorCarvalho, Ronaldo
dc.creatorLima-Filho, José Luiz de
dc.creatorArraes, Luiz Claudio
dc.creatorCrovella, Sergio
dc.date2018-08-07T11:44:23Z
dc.date2018-08-07T11:44:23Z
dc.date2009
dc.date.accessioned2023-09-26T20:56:18Z
dc.date.available2023-09-26T20:56:18Z
dc.identifierARAUJO, Jacqueline et al. Mannose Binding Lectin Gene Polymorphisms and Associated Auto-Immune Diseases in Type 1 Diabetes Brazilian Patients. Clinical Immunology (Orlando, Fla.), v. 131, n. 2, p. 254–259, maio 2009.
dc.identifier1521-7035
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27964
dc.identifier10.1016/j.clim.2008.12.010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866477
dc.descriptionEste trabalho foi apoiado por uma bolsa da FACEPE (Recife, Brasil) (APQ-0131-4.01 / 07) e por uma bolsa do Ministério da Saúde italiano RC03 / 04. Lucas Brandão e Rafael Guimarães são bolsistas de doutorado da FACEPE (IBPG-0020-2.02 / 07; IBPG-0134-2.02 / 08). A Ludovica Segat recebeu uma bolsa de subsídio (APQ-0020-4.01 / 08) da FACEPE.
dc.descriptionIn our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC). Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease. Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectLectina de ligação à manose
dc.subjectPolimorfismos
dc.subjectDiabetes Mellitus
dc.subjectTipo 1
dc.subjectTireoidite
dc.subjectAutoimune
dc.subjectDoença celíaca
dc.subjectMannose binding lectin
dc.subjectPolymorphisms
dc.subjectDiabetes mellitus
dc.subjectType 1
dc.subjectThyroiditis
dc.subjectAutoimmune
dc.subjectCeliac disease
dc.subjectAdolescente
dc.subjectDoenças Auto- Imunes / complicações
dc.subjectDoenças Autoimunes / epidemiologia
dc.subjectDoenças Auto- Imunes / genética
dc.subjectBrasil / epidemiologia
dc.subjectCriança
dc.subjectCriança, pré-escolar
dc.subjectDiabetes Mellitus Tipo 1 / complicações
dc.subjectDiabetes Mellitus, tipo 1 / epidemiologia
dc.subjectDiabetes Mellitus, tipo 1 / genética
dc.subjectFêmea
dc.subjectPredisposição Genética para Doença
dc.subjectHumanos
dc.subjectInfantil
dc.subjectMasculino
dc.subjectManose - Encadernação Lectina / genética
dc.subjectPolimorfismo de Nucleotídeo Único
dc.subjectPadrões de referência
dc.titleMannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients
dc.typeArticle


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