Characteristics of the histamine release from hamster cheek pouch mast cells stimulated by lectins from Brazilian beans and concanavalin A

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFerreira, Rosana Rossi
dc.creatorCavada, B. S.
dc.creatorMoreira, R. A.
dc.creatorOliveira, J. T A
dc.creatorGomes, J. C.
dc.date2014-05-27T11:18:07Z
dc.date2016-10-25T18:14:00Z
dc.date2014-05-27T11:18:07Z
dc.date2016-10-25T18:14:00Z
dc.date1996-10-10
dc.date.accessioned2017-04-06T00:47:50Z
dc.date.available2017-04-06T00:47:50Z
dc.identifierInflammation Research, v. 45, n. 9, p. 442-447, 1996.
dc.identifier1023-3830
dc.identifierhttp://hdl.handle.net/11449/64859
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64859
dc.identifier10.1007/BF02252314
dc.identifierWOS:A1996VH49400003
dc.identifier2-s2.0-0029792849
dc.identifierhttp://dx.doi.org/10.1007/BF02252314
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886637
dc.descriptionWe have characterized the histamine releasing effects of lectins extracted from Brazilian beans, in comparison to concanavalin A, in hamster cheek pouch cell suspensions containing mast cells. The lectins from Dioclea virgata, Canavalia brasiliensis, and Dioclea rostrata induce histamine release in a similar manner to concanavalin A, but appear to differ in potency and efficacy. The effects depended on the temperature, pH, and metabolic energy, demonstrating the non-cytotoxic nature of the histamine release. It is suggested that the lectins studied act by the same mechanism as concanavalin A (interacting with sugars in the antibodies bound to the mast cells), since high concentrations of glucose inhibit the histamine release. The lectins at high concentrations quench the histamine release. This suppression is reversed by increasing calcium concentration, suggesting that the lectins bind to the calcium that is essential for the secretion, thereby confirming and extending our previous data using the lectin from Dioclea virgata in rat peritoneal mast cells.
dc.languageeng
dc.relationInflammation Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCheek pouch
dc.subjectHamster
dc.subjectHistamine release
dc.subjectLectins
dc.subjectMast cells
dc.subjectantibody
dc.subjectcalcium
dc.subjectconcanavalin a
dc.subjectglucose
dc.subjecthistamine
dc.subjectlectin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantigen antibody reaction
dc.subjectbean
dc.subjectcheek pouch
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthamster
dc.subjecthistamine release
dc.subjectmale
dc.subjectmast cell
dc.subjectmetabolism
dc.subjectnonhuman
dc.subjectperitoneum mast cell
dc.subjectph
dc.subjecttemperature
dc.subjectAnimals
dc.subjectCheek
dc.subjectConcanavalin A
dc.subjectCricetinae
dc.subjectFemale
dc.subjectHistamine Release
dc.subjectHydrogen-Ion Concentration
dc.subjectMale
dc.subjectMast Cells
dc.subjectMouth Mucosa
dc.subjectPhosphatidylserines
dc.subjectTemperature
dc.titleCharacteristics of the histamine release from hamster cheek pouch mast cells stimulated by lectins from Brazilian beans and concanavalin A
dc.typeOtro


Este ítem pertenece a la siguiente institución