Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity

dc.creatorCaria, Alex Cleber Improta
dc.creatorNonaka, Carolina Kymie Vasques
dc.creatorPereira, Ciro Silveira
dc.creatorSoares, Milena Botelho Pereira
dc.creatorMacambira, Simone Garcia
dc.creatorSouza, Bruno Solano de Freitas
dc.date2018-12-18T12:11:11Z
dc.date2018-12-18T12:11:11Z
dc.date2018
dc.date.accessioned2023-09-26T20:55:47Z
dc.date.available2023-09-26T20:55:47Z
dc.identifierCARIA, A. C. I., et al. Exercise training-Induced changes in MicroRNAs: Beneficial regulatory effects in hypertension, type 2 diabetes, and obesity. International Journal of Molecular Sciences, v. 19, p. 3608, 2018.
dc.identifier1661-6596
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30650
dc.identifier10.3390/ijms19113608
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866332
dc.descriptionMicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such as adaptation to physical exercise, and also in disease settings, such as systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2D), and obesity. In SAH, microRNAs play a significant role in the regulation of key signaling pathways that lead to the hyperactivation of the renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, proliferation, and phenotypic change in smooth muscle cells, and the hyperactivation of the sympathetic nervous system. MicroRNAs are also involved in the regulation of insulin signaling and blood glucose levels in T2D, and participate in lipid metabolism, adipogenesis, and adipocyte differentiation in obesity, with specific microRNA signatures involved in the pathogenesis of each disease. Many studies report the benefits promoted by exercise training in cardiovascular diseases by reducing blood pressure, glucose levels, and improving insulin signaling and lipid metabolism. The molecular mechanisms involved, however, remain poorly understood, especially regarding the participation of microRNAs in these processes. This review aimed to highlight microRNAs already known to be associated with SAH, T2D, and obesity, as well as their possible regulation by exercise training.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectMicroRNAs
dc.subjectHipertensão arterial sistêmica
dc.subjectDiabetes mellitus tipo 2
dc.subjectObesidade
dc.subjectTreino de exercícios
dc.subjectMicroRNA
dc.subjectMicroRNAs
dc.subjectSystemic arterial hypertension
dc.subjectType 2 diabetes mellitus
dc.subjectObesity
dc.subjectExercise training
dc.subjectMicroRNA
dc.titleExercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity
dc.typeArticle


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