Feto-placentary pathology in human parvovirus B19 infection

Patologia feto-placentária na infecção pelo parvovírus humano B19

dc.creatorGarcia, Aparecida Gomes Pinto
dc.creatorPegado, Claudia Schwartz
dc.creatorCubel, Rita de Cassia
dc.creatorFonseca, Maria Evangelina Ferreira
dc.creatorSloboda, Ivan
dc.creatorNascimento, Jussara Pereira
dc.date2011-11-01T16:37:05Z
dc.date2011-11-01T16:37:05Z
dc.date1998
dc.date.accessioned2023-09-26T20:55:35Z
dc.date.available2023-09-26T20:55:35Z
dc.identifierGARCIA, Aparecida Gomes Pinto et al. Feto-placentary pathology in human parvovirus B19 infection. Rev. Inst. Med. Trop. São Paulo. São Paulo, v. 40, n. 3, p. 145-150, May/Jun. 1998.
dc.identifier0036-4665
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3306
dc.identifier10.1590/S0036-46651998000300003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866279
dc.descriptionSão escassas as referências aos dados histológicos relativos à infecção congênita pelo parvovírus humano B19.Apresentamos estudo morfológico de seis autópsias em que o vírus foi detectado por hibridização DNA (HIS-HDB), PCR e microscopia eletrônica (ME) em tecidos feto-placentários fixados em formol e incluídos em parafina. Estas autópsias integravam um grupo de 86 Hidropisias Fetais não Imunológicas (HFNI) que apresentaram à microscopia óptica complexo lesional sistêmico inflamatório/degenerativo de causa indeterminada. Em uma criança detectou-se processo sifilítico multivisceral com microorganismos, caracterizando infecção dupla. Os fetos exibiram quadro semelhante: hidropisia, hepato-esplenomegalia, hipoplasia pulmonar e eritroblastemia. O dado histológico específico consistiu em inclusão nuclear em eritroblastos do sangue, do tecido visceral eritropoiético e medula óssea. Cardiopatia complexa, lobulação pulmonar anômala e poliesplenia foram observadas em um caso. Em dois corações evidenciou-se fibroelastose difusa. As lesões pulmonares se manifestaram por dismaturidade e processo crônico intersticial; as hepáticas revelaram colestase, fibrose portal, proliferação canalicular, necroses hepatocitárias focais irregularmente dispostas, transformação gigantocitária e hemossiderose. No sistema nervoso central predominaram as lesões anóxicas, embora a autólise não permitisse análise minuciosa.
dc.descriptionIn view of the scarce references concerning the histological data in congenital parvovirus human B19 infection, we intend to provide a description of the pathological features observed in six autopsies.The virus was detected by DNA hybridization (ISH-H),PCR and electronmicroscopy (EM) in paraffin embedded feto-placentary tissues.These cases constitute a subset from 86 Non Immunologic Hydrops Fetalis (NIHF) cases, in which a systemic complex of inflammatory/degenerative lesions of unknown etiology was visualized by optical microscopy. In one case a syphilitic process was detected, typefying a double infection. All fetuses showed a similar pathology - hydrops, hepato-splenomegaly,lung hypoplasia and erythroblastemia, the specific histological feature being the presence of intranuclear inclusions in the erythroid progenitors, in the erythropoietic visceral tissue and in blood marrow. Complex cardiopathy allied to abnormal lung lobulation and polisplenia were observed once; in 2 cases endocardial fibroelastosis was diagnosed. The pulmonary lesions were represented by dysmaturity allied to interstitial mononuclear infiltration. The hepatic consisted of cholestasis, portal fibrosis, canalicular proliferation, hemossiderosis,focal necroses and giant cell transformation. The central nervous system lesions were predominantly anoxic although the autolysis impaired a correct diagnosis.
dc.formatapplication/pdf
dc.languageeng
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dc.rightsopen access
dc.subjectNon immunologic hydrops fetalis
dc.subjectIntrauterin infection
dc.subjectHuman parvovirus B19
dc.subjectMorphological study
dc.subjectVirus detection
dc.subjectDoenças Placentárias - patologia
dc.subjectParvovirus B19 Humano - isolamento & purificação
dc.subjectInfecções por Parvoviridae - patologia
dc.subjectParvovirus B19 Humano - ultraestrutura
dc.subjectMicroscopia Eletrônica - métodos
dc.subjectHibridização Genética
dc.subjectReação em Cadeia da Polimerase
dc.subjectAutopsia - métodos
dc.subjectHumanos
dc.subjectRecém-Nascido
dc.titleFeto-placentary pathology in human parvovirus B19 infection
dc.titlePatologia feto-placentária na infecção pelo parvovírus humano B19
dc.typeArticle


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