Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol

dc.creatorFischer, Juliana de Saldanha da Gama
dc.creatorCarvalho, Paulo Costa
dc.creatorFonseca, Clovis Orlando da
dc.creatorLiao, Lujian
dc.creatorDegrave, Wim M.
dc.creatorCarvalho, Maria da Gloria da Costa
dc.creatorYates, John R.
dc.creatorDomont, Gilberto B.
dc.date2018-04-03T11:25:29Z
dc.date2018-04-03T11:25:29Z
dc.date2011
dc.date.accessioned2023-09-26T20:54:21Z
dc.date.available2023-09-26T20:54:21Z
dc.identifierFISCHER, Juliana de Saldanha da Gama; et al. A chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. J Proteome Res., v.10, n.1, p.153-160, Jan. 2011.
dc.identifier1535-3893
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25571
dc.identifier10.1021/pr100677g
dc.identifier1535-3907
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865939
dc.descriptionGlioblastoma multiform (GBM) is by far the most malignant glioma. We have introduced a new treatment for GBMs that comprises the inhalation of a naturally occurring terpene with chemotherapeutic properties known as perillyl alcohol (POH). Clinical trial results on recurrent GBM patients showed that POH extends the average life by more than eight months, temporarily slows tumor growth, and in some cases even decreases tumor size. After approximately seven months, the tumor continues to grow and leads to a dismal prognosis. To investigate how these tumors become resistant to POH, we generated an A172 human glioblastoma cell culture tolerant to 0.06 mM of POH (A172r). We used Multidimensional Protein Identification Technology (MudPIT) to compare the protein expression profile of A172r cells to the established glioblastoma A172 cell line. Our results include a list of identified proteins unique to either the resistant or the nonresistant cell line. These proteins are related to cellular growth, negative apoptosis regulation, Ras pathway, and other key cellular functions that could be connected to the underlying mechanisms of resistance.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Chemical Society
dc.rightsrestricted access
dc.subjectGlioblastoma
dc.subjectresistência
dc.subjectperfil de proteína
dc.subjectGlioblastoma
dc.subjectMudPIT
dc.subjectperillyl alcohol
dc.subjectA172 cells
dc.subjectresistant
dc.subjectprotein profile
dc.titleChemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol
dc.typeArticle


Este ítem pertenece a la siguiente institución