The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains

dc.creatorVan Dooren, Sonia
dc.creatorPybus, Oliver G.
dc.creatorSalemi, Marco
dc.creatorLiu, Hong-Fei
dc.creatorGoubau, P.
dc.creatorRemondegui, Carlo
dc.creatorTalarmin, Antoine
dc.creatorGotuzzo, Eduardo
dc.creatorAlcantara, Luiz Carlos Júnior
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorVandamme, Anne-Mieke
dc.date2014-08-05T16:59:33Z
dc.date2014-08-05T16:59:33Z
dc.date2004
dc.date.accessioned2023-09-26T20:54:03Z
dc.date.available2023-09-26T20:54:03Z
dc.identifierVAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004.
dc.identifier0737-4038
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8133
dc.identifier10.1093/molbev/msh053
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865853
dc.descriptionThe evolutionary rate of the human T-cell lymphotropic virus type-1 (HTLV-1) is considered to be very low, in strong contrast to the related human retrovirus HIV. However, current estimates of the HTLV-1 rate rely on the anthropological calibration of phylogenies using assumed dates of human migration events. To obtain an independent rate estimate, we analyzed two variable regions of the HTLV-1 genome (LTR and env) from eight infected families. Remarkable genetic stability was observed, as only two mutations in LTR (756 bp) and three mutations in env (522 bp) occurred within the 16 vertical transmission chains, including one ambiguous position in each region. The evolutionary rate in HTLV-1 was then calculated using a maximum-likelihood approach that used the highest and lowest possible times of HTLV-1 shared ancestry, given the known transmission histories. The rates for the LTR and env regions were 9.58 3 10 8–1.25 3 10 5 and 7.84310 7 –2.33310 5nucleotide substitutions per site per year, respectively. A more precise estimate was obtained for the combined LTR-env data set, which was 7.06310 7–1.38310 5substitutions per site per year. We also note an interesting correlation between the occurrence of mutations in HTLV-1 and the age of the individual infected.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectVertical transmission
dc.subjectEvolutionary rate
dc.subjectMolecular clock
dc.subjectEvolução Biológica
dc.subjectVírus 1 Linfotrópico T Humano/genética
dc.subjectTransmissão Vertical de Doença Infecciosa
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectFeminino
dc.subjectInfecções por HTLV-I/transmissão
dc.subjectHumanos
dc.subjectFunções Verossimilhança
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectMutação
dc.subjectLinhagem
dc.subjectFilogenia
dc.subjectDistribuição de Poisson
dc.titleThe low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
dc.typeArticle


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