Immunohistochemical assessment of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors.

dc.creatorDultra, Fátima Karoline Araújo Alves
dc.creatorBarros, Adna Conceição
dc.creatorBarbosa, Helenemarie Schaer
dc.creatorFigueiredo, Andreia Leal
dc.creatorGurgel, Clarissa Araújo Silva
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorCarvalho, Ana Maria da Silva
dc.creatorSantos, Jean Nunes dos
dc.date2014-11-19T17:25:38Z
dc.date2014-11-19T17:25:38Z
dc.date2012
dc.date.accessioned2023-09-26T20:53:34Z
dc.date.available2023-09-26T20:53:34Z
dc.identifierDULTRA, F. K. A. et al. Immunohistochemical assessment of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. Journal of Oral Pathology & Medicine, v. 41, n. 1, p. 47-53, 2012.
dc.identifier1600-0714
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8920
dc.identifier10.1111/j.1600-0714.2011.01052.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865716
dc.descriptionOBJECTIVE: The aim of this study was to investigate the presence of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. METHODS: Twenty-seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E-cadherin. RESULTS: A significant difference regarding the mean density of CD1a-positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a-positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a-positive cells were detected in one mucoepidermoid carcinoma case, and six low-grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a-positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E-cadherin between tumors (P = 0.73), but it was detected in 24 cases. CONCLUSIONS: The lack of CD1a-positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors although we did not demonstrate significance.
dc.formatapplication/pdf
dc.languageeng
dc.publisherJohn Wiley & Sons Ltd
dc.rightsopen access
dc.subjectCell adhesion
dc.subjectDendritic cell
dc.subjectImmunohistochemistry
dc.subjectSalivary gland tumors
dc.subjectAntígenos CD1/análise
dc.subjectCaderinas/análise
dc.subjectCélulas de Langerhans/patologia
dc.subjectNeoplasias das Glândulas Salivares/patologia
dc.subjectGlândulas Salivares Menores/patologia
dc.subjectAdenocarcinoma/patologia
dc.subjectAdenoma Pleomorfo/patologia
dc.subjectCarcinoma Adenoide Cístico/patologia
dc.subjectCarcinoma Mucoepidermoide/patologia
dc.subjectContagem de Células
dc.subjectCorantes/uso diagnóstico
dc.subjectCélulas Dendríticas/patologia
dc.subjectEpitélio/patologia
dc.subjectFeminino
dc.subjectHumanos
dc.subjectProcessamento de Imagem Assistida por Computador/métodos
dc.subjectImuno-Histoquímica
dc.subjectCélulas de Langerhans/imunologia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titleImmunohistochemical assessment of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors.
dc.typeArticle


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