Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion

dc.creatorLima, Josilene Borges T
dc.creatorRibeiro, Guilherme de Sousa
dc.creatorCordeiro, Soraia Machado
dc.creatorGouveia, Edilane Lins
dc.creatorSalgado, Kátia M
dc.creatorSpratt, Brian G
dc.creatorGodoy, Daniel
dc.creatorReis, Mitermayer Galvão dos
dc.creatorKo, Albert Icksang
dc.creatorReis, Joice Neves
dc.date2012-11-14T19:54:31Z
dc.date2012-11-14T19:54:31Z
dc.date2010
dc.date.accessioned2023-09-26T20:53:13Z
dc.date.available2023-09-26T20:53:13Z
dc.identifierLIMA, J. B. et al. Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion. Journal of Infectious Diseases, v. 202, n. 10, p. 1577-1584, nov. 2010.
dc.identifier1537-6613
dc.identifierPMID 20932170
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5814
dc.identifier10.1086/656778
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865612
dc.descriptionince the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHaemophilus influenzae
dc.subjectnon-type b H. influenzae
dc.subjectMeningitis
dc.subjectHib conjugate vaccine
dc.subjectVirulence
dc.subjectIS1016-bexA deletion
dc.subjectMolecular epidemiology
dc.subjectTransportadores de Cassetes de Ligação de ATP/genética
dc.subjectProteínas de Bactérias/genética
dc.subjectHaemophilus/genética
dc.subjectMeningite por Haemophilus
dc.subjectVirulencia/genética
dc.titlePoor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion
dc.typeArticle


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