Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak

dc.creatorMir, Daiana
dc.creatorDelatorre, Edson
dc.creatorBonaldo, Myrna
dc.creatorOliveira, Ricardo Lourenço de
dc.creatorVicente, Ana Carolina
dc.creatorBello, Gonzalo
dc.date2017-10-17T15:04:14Z
dc.date2017-10-17T15:04:14Z
dc.date2017
dc.date.accessioned2023-09-26T20:53:03Z
dc.date.available2023-09-26T20:53:03Z
dc.identifierMIR, Daiana; et al. Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak. Scientifc Reports, v.7:7385, 9p, Aug. 2017.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/22845
dc.identifier10.1038/s41598-017-07873-7
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865567
dc.descriptionYellow fever virus (YFV) strains circulating in the Americas belong to two distinct genotypes (I and II) that have diversified into several concurrent enzootic lineages. Since 1999, YFV genotype I has spread outside endemic regions and its recent (2017) reemergence in non-endemic Southeastern Brazilian states fuels one of the largest epizootic of jungle Yellow Fever registered in the country. To better understand this phenomenon, we reconstructed the phylodynamics of YFV American genotypes using sequences from nine countries sampled along 60 years, including strains from Brazilian 2017 outbreak. Our analyses reveals that YFV genotypes I and II follow roughly similar evolutionary and demographic dynamics until the early 1990s, when a dramatic change in the diversification process of the genotype I occurred associated with the emergence and dissemination of a new lineage (here called modern). Trinidad and Tobago was the most likely source of the YFV modern-lineage that spread to Brazil and Venezuela around the late 1980s, where it replaced all lineages previously circulating. The modern-lineage caused all major YFV outbreaks detected in non-endemic South American regions since 2000, including the 2017 Brazilian outbreak, and its dissemination was coupled to the accumulation of several amino acid substitutions particularly within non-structural viral proteins.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsopen access
dc.subjectVírus da Febre Amarela
dc.subjectAméricas
dc.subjectSurto
dc.subjectBrasil
dc.subjectGenótipos
dc.subjectFilodinâmica
dc.subjectYellow fever virus
dc.subjectAmericas
dc.subjectBrazilian Outbreak
dc.subjectBrazil
dc.subjectgenotypes
dc.subjectPhylodinamics
dc.titlePhylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak
dc.typeArticle


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