Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: a systematic review and meta-analysis of individual participant data

dc.creatorSguassero, Yanina
dc.creatorRoberts, Karen N.
dc.creatorHarvey, Guillermina B.
dc.creatorComandé, Daniel
dc.creatorCiapponi, Agustín
dc.creatorCuesta, Cristina B.
dc.creatorAguiar, Camila
dc.creatorCastro, Ana M. de
dc.creatorDanesi, Emmaría
dc.creatorAndrade, Ana L. de
dc.creatorLana, Marta de
dc.creatorEscribà, Josep M.
dc.creatorFabbro, Diana L.
dc.creatorFernandes, Cloé D.
dc.creatorFlores-Chávez, María
dc.creatorHasslocher-Moreno, Alejandro Marcel
dc.creatorJackson, Yves
dc.creatorLacunza, Carlos D.
dc.creatorMachado-de-Assis, Girley F.
dc.creatorMaldonado, Marisel
dc.creatorMeira, Wendell S. F.
dc.creatorMolina, Israel
dc.creatorMonje-Rumi, María M.
dc.creatorMuñoz-San Martín, Catalina
dc.creatorMurcia, Laura
dc.creatorCastro, Cleudson Nery de
dc.creatorSánchez Negrette, Olga
dc.creatorSegovia, Manuel
dc.creatorSilveira, Celeste A. N.
dc.creatorSolari, Aldo
dc.creatorSteindel, Mário
dc.creatorStreiger, Mirtha L.
dc.creatorVera de Bilbao, Ninfa
dc.creatorZulantay, Inés
dc.creatorSosa-Estani, Sergio
dc.date2019-02-11T11:37:53Z
dc.date2019-02-11T11:37:53Z
dc.date2018
dc.date.accessioned2023-09-26T20:52:57Z
dc.date.available2023-09-26T20:52:57Z
dc.identifierSGUASSERO, Yanina et al. Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: a systematic review and meta-analysis of individual participant data. International Journal of Infectious Diseases, v. 73, p. 93-101, 2018.
dc.identifier1201-9712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31527
dc.identifier10.1016/j.ijid.2018.05.019
dc.identifier1878-3511
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865534
dc.descriptionAlejandro M. Hasslocher-Morenon - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
dc.descriptionYanina Sguasseroa,b,, Karen N. Robertsc , Guillermina B. Harveyc , Daniel Comandéd, Agustín Ciapponid, Cristina B. Cuestac, Camila Aguiare, Ana M. de Castrof, Emmaría Danesig, Ana L. de Andradeh, Marta de Lanai, Josep M. Escribàj, Diana L. Fabbrok, Cloé D. Fernandesl, María Flores-Chávezm, Alejandro M. Hasslocher-Morenon, Yves Jacksono,p, Carlos D. Lacunzaq, Girley F. Machado-de-Assisr, Marisel Maldonados, Wendell S.F. Meirat, Israel Molinau,v, María M. Monje-Rumiw, Catalina Muñoz-San Martínx,y, Laura Murciaz,aa, Cleudson Nery de Castrobb,cc, Olga Sánchez Negrettedd,ee, Manuel Segoviaz,aa, Celeste A.N. Silveiracc, Aldo Solariff, Mário Steindelgg, Mirtha L. Streigerk,Ninfa Vera de Bilbaos, Inés Zulantayy, Sergio Sosa-Estanib,d, aCentro Rosarino de Estudios Perinatales, Rosario, Argentina b Instituto Nacional de Parasitología, Fatala Chaben-ANLIS, Buenos Aires, Argentina c Facultad de Ciencias Económicas y Estadística, Universidad Nacional de Rosario, Argentina d Instituto de Efectividad Clínica y Sanitaria. CONICET, Buenos Aires, Argentina e Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazil f Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil gCentro Nacional de Investigación y Diagnóstico en Endemoepidemias (CeNDIE-ANLIS), Buenos Aires, Argentina hDepartamento de Saúde Coletiva, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil i Departamento de Análise Clínica, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil j Medical Department, Médecins sans Frontières, Barcelona, Spain kCentro de Investigaciones sobre Endemias Nacionales (CIEN), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina l Instituto de Pesquisa Biológica, Laboratório Central, Fundação Estadual de Produção e Pesquisa em Saúde, Porto Alegre, RS, Brazil m Unidad de Leishmaniasis, Servicio de Parasitología, Instituto de Salud Carlos III, Madrid, España n Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Brazil oDivision of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland p Institute of Global Health, University of Geneva, Geneva, Switzerland qDirección de Primer Nivel de Atención, Área Operativa N LV, Salta, Argentina r Departamento de Ciências Básicas da Vida, Universidade Federal de Juiz de Fora, Campus Governador Valadares, Brazil s Departamento de Medicina Tropical, Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Paraguay t Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal do Triangulo Mineiro, Brazil u Infectious Diseases Department, Hospital Universitario Vall d’Hebron, Barcelona, Spain v International Health Program of the Catalan Institute of Health (PROSICS), Barcelona, Spain w Laboratorio de Patología Experimental, Universidad Nacional de Salta, Salta, Argentina x Laboratorio de Ecología, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile y Laboratorio de Parasitología Básico-Clínico Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile z Unidad Regional de Medicina Tropical, Servicio de Microbiología, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, España aaDepartamento de Genética y Microbiología, Universidad de Murcia, Espinardo, Murcia, España bb Escola de Saúde e Medicina, Universidade Católica de Brasília, Brazil ccNúcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brazil dd Cátedra de Inmunología, Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Argentina eeCátedra de Química Biológica, Facultad de Ciencias Exactas, Universidad Nacional de Salta, Argentina ff Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile ggDepartamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Brazil
dc.descriptionObjective: To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. Methods: A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO database (http://www.crd.york.ac.uk/PROSPERO; CRD42012002162). Results: A total of 27 studies (1296 subjects) conducted in eight countries were included. The risk of bias was low for all domains in 17 studies (63.0%). Nine hundred and thirteen subjects were assessed (149 seroreversion events, 83.7% censored data) for enzyme-linked immunosorbent assay (ELISA), 670 subjects (134 events, 80.0% censored) for indirect immunofluorescence assay (IIF), and 548 subjects (99 events, 82.0% censored) for indirect hemagglutination assay (IHA). A higher probability of seroreversion was observed within a shorter time span in subjects aged 1–19 years compared to adults. The chance of seroreversion also varied according to the country where the infection might have been acquired. For instance, the pooled adjusted hazard ratio between children/adolescents and adults for the IIF test was 1.54 (95% confidence interval 0.64–3.71) for certain countries of South America (Argentina, Bolivia, Chile, and Paraguay) and 9.37 (95% confidence interval 3.44–25.50) for Brazil. Conclusions: The disappearance of anti-T. cruzi antibodies was demonstrated along the course of followup. An interaction between age at treatment and country setting was found.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectChronic disease
dc.subjectFollow-up studies
dc.subjectIndividual participant data
dc.subjectMeta-analysis
dc.subjectSerologic tests
dc.titleCourse of serological tests in treated subjects with chronic Trypanosoma cruzi infection: a systematic review and meta-analysis of individual participant data
dc.typeArticle


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