| dc.creator | Ramos, Aline de Souza | |
| dc.creator | Ribeiro, Joyce Benzaquem | |
| dc.creator | Teixeira, Bruna Gomes | |
| dc.creator | Ferreira, José Luiz Pinto | |
| dc.creator | Silva, Jefferson Rocha de Andrare | |
| dc.creator | Ferreira, Alexandre do Amaral | |
| dc.creator | Souza, Rodrigo Octavio Mendonça Alves de | |
| dc.creator | Amaral, Ana Claudia Fernandes | |
| dc.date | 2021-06-01T12:16:45Z | |
| dc.date | 2021-06-01T12:16:45Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-09-26T20:52:50Z | |
| dc.date.available | 2023-09-26T20:52:50Z | |
| dc.identifier | RAMOS, Aline de Souza et al. Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger. Brazilian Journal of Microbiology, v. 46, n. 1, p. 261-264, 2015. | |
| dc.identifier | 1678-4405 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/47471 | |
| dc.identifier | 10.1590/S1517-838246120131020 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8865499 | |
| dc.description | The monoterpenoid 1,8-cineole is obtained from the leaves of Eucalyptus globulus and it has important biological activities. It is a cheap natural substrate because it is a by-product of the Eucalyptus
cultivation for wood and pulp production. In this study, it was evaluated the potential of three filamentous fungi in the biotransformation of 1,8-cineole. The study was divided in two steps: first, reactions were carried out with 1,8-cineole at 1 g/L for 24 h; afterwards, reactions were carried out with
substrate at 5 g/L for 5 days. The substrate was hydroxylated into 2-exo-hydroxy-1,8-cineole and
3-exo-hydroxy-1,8-cineole by fungi Mucor ramannianus and Aspergillus niger with high stereoselectivity. Trichoderma harzianum was also tested but no transformation was detected. M.
ramannianus led to higher than 99% of conversion within 24 h with a starting high substrate concentration (1 g/L). When substrate was added at 5 g/L, only M. ramannianus was able to catalyze the reaction, but the conversion level was 21.7% after 5 days. Both products have defined stereochemistry
and could be used as chiral synthons. Furthermore, biological activity has been described for
3-exo-hydroxy-1,8-cineol. To the best of our knowledge, this is the first report on the use of M.
ramannianus in this reaction. | |
| dc.format | application/pdf | |
| dc.language | por | |
| dc.rights | open access | |
| dc.subject | Biotransformation | |
| dc.subject | Monoterpene | |
| dc.subject | 1,8-cineole | |
| dc.subject | Mucor Ramannianus | |
| dc.subject | Aspergillus Niger | |
| dc.title | Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger | |
| dc.type | Article | |
