Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines

dc.creatorOliveira, Viviane Sampaio Boaventura de
dc.creatorSantos, Claire da Silva
dc.creatorCardoso, Cristina Ribeiro de Barros
dc.creatorAndrade, José de
dc.creatordosSantos, Washington Luis Conrado
dc.creatorClarêncio, Jorge
dc.creatorSilva, João Santana da
dc.creatorBorges, Valeria de Matos
dc.creatorBarral Netto, Manoel
dc.creatorBrodskyn, Claudia Ida
dc.creatorBarral, Aldina Maria Prado
dc.date2012-11-14T20:29:20Z
dc.date2012-11-14T20:29:20Z
dc.date2010
dc.date.accessioned2023-09-26T20:51:48Z
dc.date.available2023-09-26T20:51:48Z
dc.identifierBOAVENTURA, V. S. et al. Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. European Journal of Immunology, v. 40, n. 10, p. 2830-2836, out. 2010.
dc.identifier0014-2980
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5815
dc.identifier10.1002/eji.200940115
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8865203
dc.descriptionMucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1ß, IL-23, IL-6 and TGF-ß) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHuman
dc.subjectMucosal leishmaniasis
dc.subjectNeutrophils
dc.subjectTh17
dc.subjectInterleucina-17/Imunologia
dc.subjectLeishmania/Imunologia
dc.subjectLeishmaniose Mucocutânea/Imunologia
dc.subjectNeutrófilos/Imunologia
dc.titleHuman mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines
dc.typeArticle


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