Antitumor effect of snake venoms

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDa Silva, R. J.
dc.creatorFecchio, D.
dc.creatorBarraviera, B.
dc.date2014-05-27T11:18:03Z
dc.date2016-10-25T18:13:43Z
dc.date2014-05-27T11:18:03Z
dc.date2016-10-25T18:13:43Z
dc.date1996-01-01
dc.date.accessioned2017-04-06T00:46:50Z
dc.date.available2017-04-06T00:46:50Z
dc.identifierJournal of Venomous Animals and Toxins, v. 2, n. 2, p. 79-90, 1996.
dc.identifier0104-7930
dc.identifierhttp://hdl.handle.net/11449/64714
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64714
dc.identifier10.1590/S0104-79301996000200002
dc.identifierS0104-79301996000200002
dc.identifier2-s2.0-0029830157
dc.identifierhttp://dx.doi.org/10.1590/S0104-79301996000200002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886508
dc.descriptionThe search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells with Bothrops jararaca venom. Considering these findings, we postulate that both Borhrops jararaca and Crotalus durissus terrificus venoms can act directly on tumor cells. In addition, we propose an indirect mechanism, based on the stimulation of the inflammatory response, to inhibit tumor growth and to promote its rejection.
dc.languageeng
dc.relationJournal of Venomous Animals and Toxins
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBothrops jararaca
dc.subjectCancer
dc.subjectCrotalus durissus terrificus
dc.subjectInflammation
dc.subjectSnakes
dc.subjectVenom
dc.subjectantineoplastic agent
dc.subjectbatroxobin
dc.subjectinterleukin 6
dc.subjectsnake venom
dc.subjectantineoplastic activity
dc.subjectcancer inhibition
dc.subjectcytolysis
dc.subjectdrug mechanism
dc.subjectehrlich ascites tumor cell
dc.subjecthuman
dc.subjectinflammation
dc.subjectleukocyte count
dc.subjectlymphokine activated killer cell
dc.subjectmacrophage
dc.subjectmononuclear cell
dc.subjectnonhuman
dc.subjectpolymorphonuclear cell
dc.subjectreview
dc.subjectsarcoma
dc.subjectsnakebite
dc.subjecttumor cell
dc.titleAntitumor effect of snake venoms
dc.typeOtro


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