Aureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin

dc.creatorSacramento, Carolina Q.
dc.creatorMarttorelli, Andressa
dc.creatorRodrigues, Natalia Fintelman
dc.creatorFreitas, Caroline S. de
dc.creatorMelo, Gabrielle R. de
dc.creatorRocha, Marco E. N.
dc.creatorKaiser, Carlos R.
dc.creatorRodrigues, Katia F.
dc.creatorCosta, Gisela L. da
dc.creatorAlves, Cristiane M.
dc.creatorSantos Filho, Osvaldo
dc.creatorBarbosa, Jussara P.
dc.creatorSouza, Thiago Moreno L.
dc.date2015-11-17T16:12:08Z
dc.date2015-11-17T16:12:08Z
dc.date2015
dc.date.accessioned2023-09-26T20:50:46Z
dc.date.available2023-09-26T20:50:46Z
dc.identifierSACRAMENTO, Carolina Q. et al. Aureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin. Plos One, v.10, n.10, e0139236, 17p, Oct. 2015.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12253
dc.identifier10.1371/journal. pone.0139236
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864914
dc.descriptionThe influenza virus causes acute respiratory infections, leading to high morbidity and mortality in groups of patients at higher risk. Antiviral drugs represent the first line of defense against influenza, both for seasonal infections and pandemic outbreaks. Two main classes of drugs against influenza are in clinical use: M2-channel blockers and neuraminidase inhibitors. Nevertheless, because influenza strains that are resistant to these antivirals have been described, the search for novel compounds with different mechanisms of action is necessary. Here, we investigated the anti-influenza activity of a fungi-derived natural product, aureonitol. This compound inhibited influenza A and B virus replication. This compound was more effective against influenza A(H3N2), with an EC50 of 100 nM. Aureonitol cytoxicity was also very low, with a CC50 value of 1426 μM. Aureonitol inhibited influenza hemagglutination and, consequently, significantly impaired virus adsorption. Molecular modeling studies revealed that aureonitol docked in the sialic acid binding site of hemagglutinin, forming hydrogen bonds with highly conserved residues. Altogether, our results indicate that the chemical structure of aureonitol is promising for future anti-influenza drug design.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPlos One
dc.rightsopen access
dc.subjectGlycoprotein Hemagglutinin
dc.subjectVírus da Influenza A
dc.subjectVírus da Influenza B
dc.subjectAureonitol
dc.subjectFungi-Derived Tetrahydrofuran
dc.subjectProteína HN
dc.subjectFungos
dc.subjectInfluenza
dc.subjectResistência a Medicamentos
dc.titleAureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin
dc.typeArticle


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