Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases

dc.creatorCarvalho, Ana Paula Mendes
dc.creatorFabri, Angélica da Conceição Oliveira Coelho
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorLana, Francisco Carlos Félix
dc.date2016-02-26T19:05:36Z
dc.date2016-02-26T19:05:36Z
dc.date2015
dc.date.accessioned2023-09-26T20:50:38Z
dc.date.available2023-09-26T20:50:38Z
dc.identifierCARVALHO, Ana Paula Mendes et al. Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases. BMC Infectious Diseases, vol. 15, p. 219, 2015
dc.identifier1471-2334
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12886
dc.identifier10.1186/s12879-015-0955-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864871
dc.descriptionBackground: The diagnosis of leprosy is based on clinical symptoms of the disease, which may not be sufficient to ensure early diagnosis. The development of effective tools for the early detection of infection, such as rapid tests that can be applied by non-specialists for early-stage leprosy identification, has been considered a research priority and may contribute to overcoming the complications associated with late diagnosis. The aim of this study was to analyze the factors associated with anti-phenolic glycolipid-I (PGL-I) seropositivity among the household contacts of leprosy cases. Methods: A cross-sectional study of individuals from the northeastern municipalities of the state of Minas Gerais, Brazil, was performed. Anti-PGL-I seropositivity was evaluated by assessing specific antibody production using the ML Flow test. A Poisson regression with a robust error variance was used to evaluate the relationship between anti-PGL-I seropositivity and the independent variables investigated. Results: The overall anti-PGL-I seropositivity was 13.5 %, and among the contacts of leprosy cases that were classified as paucibacillary or multibacillary, it was 8.4 and 17.3 %, respectively. The factors associated with the variation of anti-PGL-I seropositivity among the study population were the presence of signs suggestive of leprosy (PR = 3.68; 95 % CI: 1.56–8.71), the operational leprosy classification (PR = 2.17; 95 % CI: 1.22–3.86) and grade 1 (PR = 1.83; 95 % CI: 1.02–3.26) or grade 2 disability (PR = 2.42; 95 % CI: 1.02–5.47) of the index leprosy case. Conclusions: The presence of signs suggestive of leprosy and the operational classification of leprosy cases were associated with anti-PGL-I seropositivity. The serological tests available for leprosy are not considered to be diagnostic tests but can be used as auxiliary assessments in combination with clinical parameters to identify exposed individuals at high risk of developing leprosy and those exhibiting the initial stages of this disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectLeprosy Case
dc.subjectSlit Skin Smear
dc.subjectLeprosy Patient
dc.subjectMultibacillary Leprosy
dc.subjectIndeterminate Form
dc.subjectOperational Classification
dc.subjectBCG Vaccination Status
dc.subjectSmear Test
dc.subjectPaucibacillary Patient
dc.subjectLepromatous Leprosy
dc.subjectTuberculoid Form
dc.subjectPoisson Regression Model
dc.subjectLeprosy Control
dc.titleFactors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases
dc.typeArticle


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