Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice

dc.creatorOliveira, Maria Talita Pacheco de
dc.creatorCoutinho, Diego de Sá
dc.creatorGuterres, Sílvia Stanisçuaski
dc.creatorPohlmann, Adriana Raffin
dc.creatorSilva, Patrícia Machado Rodrigues e
dc.creatorMartins, Marco Aurélio
dc.creatorBernardi, Andressa
dc.date2021-06-28T13:54:16Z
dc.date2021-06-28T13:54:16Z
dc.date2021
dc.date.accessioned2023-09-26T20:50:36Z
dc.date.available2023-09-26T20:50:36Z
dc.identifierOLIVEIRA, Maria Talita Pacheco de et al. Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice. Pharmaceutics, v. 13, n.683, 17 p, May 2021.
dc.identifier1999-4923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/47896
dc.identifier10.3390/pharmaceuthics13050683
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864862
dc.descriptionAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are inflammatory and oxidative imbalance lung conditions with no successful pharmacological therapy and a high mortality rate. Resveratrol (RSV) is a plant-derived stilbene that presents anti-inflammatory and an tioxidant effects. However, its therapeutic application remains limited due to its poor bioavailability, which can be solved by the use of nanocarriers. Previously, we demonstrated that nanoencapsulated RSV (RSV-LNC) pre-treatment, performed 4 h before lipopolysaccharide (LPS) stimulation in mice, increased its anti-inflammatory properties. In this study, we evaluated the anti-inflammatory and antioxidant effects, and lung distribution of RSV-LNCs administered therapeutically (6 h post LPS exposure) in a lung injury mouse model. The results showed that RSV-LNCs posttreatment improved lung function and diminished pulmonary inflammation. Moreover, RSV-LNC treatment enhanced the antioxidant catalase level together with a decrease in the oxidative biomarker in mouse lungs, which was accompanied by an increase in pulmonary Nrf2 antioxidant expression. Finally, the presence of RSV in lung tissue was significantly detected when mice received RSV-LNCs but not when they received RSV in its free form. Together, our results confirm that RSV nanoencapsulation promotes an increase in RSV bioavailability, enhancing its therapeutic effects in an LPS-induced lung injury model.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectLesão pulmonar aguda
dc.subjectSíndrome do desconforto respiratório agudo
dc.subjectInflamação
dc.subjectReceptores de Lipopolissacarídeos
dc.subjectResveratrol
dc.subjectAcute lung injury
dc.subjectAcute respiratory distress syndrome
dc.subjectInflammation
dc.subjectLPS
dc.subjectResveratrol
dc.subjectNanocarriers
dc.subjectReceptores de Lipopolissacarídeos
dc.titleResveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice
dc.typeArticle


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