Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

dc.creatorMekhaiel, David N. A.
dc.creatorDaniel-Ribeiro, Cláudio Tadeu
dc.creatorCooper, Philip J.
dc.creatorPleass, Richard J.
dc.date2018-04-17T16:13:58Z
dc.date2018-04-17T16:13:58Z
dc.date2011
dc.date.accessioned2023-09-26T20:49:25Z
dc.date.available2023-09-26T20:49:25Z
dc.identifierMEKHAIEL, David N. A. et al. Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?. Trends in Parasitology, v.27, n.12, p.523-529, 2011.
dc.identifier1471-4922
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25907
dc.identifier1471-5007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864515
dc.descriptionThe ‘hygiene hypothesis’, or lack of microbial and parasite exposure during early life, is postulated as an explanation for the recent increase in autoimmune and allergic diseases in developed countries. The favored mechanism is that microbial and parasite-derived products interact directly with pathogen recognition receptors to subvert proinflammatory signaling via T regulatory cells, thereby inducing anti-inflammatory effects and control of autoimmune disease. Parasites, such as helminths, are considered to have a major role in the induction of immune regulatory mechanisms among children living in developing countries. Invoking Occam’s razor, we believe we can select an alternative mechanism to explain the hygiene hypothesis, based on antibody-mediated inhibition of immune responses that may more simply explain the available evidence.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectParasitos
dc.subjectAnticorpos
dc.subjecthipótese de higiene
dc.subjecthygiene hypothesis
dc.subjectantibodies
dc.subjectParasites
dc.titleDo regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?
dc.typeArticle


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