Manson's schistosomiasis in the undernourished mouse: some recent findings

dc.creatorCoutinho, Eridan M.
dc.creatorOliveira, Sheilla A. de
dc.creatorBarros, Andréia F. de
dc.creatorSilva, Fabiana L.
dc.creatorRamos, Renata P.
dc.date2018-04-26T12:34:37Z
dc.date2018-04-26T12:34:37Z
dc.date2010
dc.date.accessioned2023-09-26T20:49:14Z
dc.date.available2023-09-26T20:49:14Z
dc.identifierCOUTINHO, E. M. et al. Manson’s schistosomiasis in the undernourished mouse: some recent findings. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 359–366, jul. 2010.
dc.identifier1678-8060
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26122
dc.identifier10.1590/S0074-02762010000400002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864463
dc.descriptionThis paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-gamma, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-gamma, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectDesnutrição
dc.subjectImunopatologia
dc.subjectSchistosoma mansoni
dc.subjectUndernutrition
dc.subjectImmunopathology
dc.subjectAnimais
dc.subjectAnticorpos, Helmintos / imunologia
dc.subjectCitocinas / imunologia
dc.subjectImunidade, Humoral / imunologia
dc.subjectCirrose Hepática Experimental / Imunologia
dc.subjectCirrose Hepática Experimental / parasitologia
dc.subjectCirrose Hepática Experimental / patologia
dc.subjectDesnutrição / imunologia
dc.subjectDesnutrição / patologia
dc.subjectRatos
dc.subjectRatos, Knockout
dc.subjectModelos Animal
dc.subjectSchistosoma mansoni / imunologia
dc.subjectEsquistossomose mansoni / imunologia
dc.subjectEsquistossomose mansoni / patologia
dc.titleManson's schistosomiasis in the undernourished mouse: some recent findings
dc.typeArticle


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