Brasil | Article

A proposed new clinical staging system for patients with mucosal leishmaniasis

dc.creatorLessa, Hélio Andrade
dc.creatorLessa, Marcus Miranda
dc.creatorGuimarães, Luiz Henrique Santos
dc.creatorLima, Clara Mônica Figueiredo de
dc.creatorArruda, Sérgio Marcos
dc.creatorMachado, Paulo Roberto Lima
dc.creatorCarvalho Filho, Edgar Marcelino
dc.date2017-05-29T18:16:55Z
dc.date2017-05-29T18:16:55Z
dc.date2012
dc.date.accessioned2023-09-26T20:49:12Z
dc.date.available2023-09-26T20:49:12Z
dc.identifierLESSA, H. A. et al. A proposed new clinical staging system for patients with mucosal leishmaniasis. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 106, n. 6, p. 376–381, 2012.
dc.identifier0035-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19037
dc.identifier10.1016/j.trstmh.2012.03.007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864456
dc.descriptionArruda, Sérgio Marcos “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionUS National Institutes of Health.
dc.descriptionMucosal leishmaniasis (ML) occurs mainly in areas where Leishmania braziliensis is transmitted. It affects predominantly the nasal mucosa and, in more severe forms, can lead to significant tissue destruction. There is no standard method for grading the severity of disease. We categorised 50 patients with ML according to a proposed new clinical staging system. Their age ranged from 10 to 86 y (mean ± SD: 36 ± 16 y) and 43 (86%) patients were male. The different degrees of evolution of mucosal disease, from the initial stage to the more severe long-term cases, enabled ML to be graded into five stages. Stage I is characterised by nodular lesions of the mucosa without ulceration. Stage II is represented by superficial mucosal ulcerations with concomitant fine granular lesions. Stage III is characterised by deep mucosal ulcerations with granular tissue formation. In stage IV there are irreversible lesions leading to perforation of the cartilaginous nasal septum with necrosis. In stage V the nasal pyramid is compromised with alterations of facial features as a consequence of severe tissue destruction. These stages may be useful in characterising the severity of the lesion and optimising therapeutic outcome.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxfor University Press
dc.rightsopen access
dc.subjectLeishmaniose
dc.subjectLeishmaniose mucosa
dc.subjectEstágio da doença
dc.subjectMucosa nasal
dc.subjectDoenças do nariz
dc.subjectBrasil
dc.subjectLeishmaniasis
dc.subjectMucosal leishmaniasis
dc.subjectDisease stage
dc.subjectNasal mucosa
dc.subjectNose diseases
dc.subjectBrazil
dc.subjectLeishmaniose
dc.subjectMucosa nasal
dc.subjectDoenças do nariz
dc.subjectBrazil
dc.titleA proposed new clinical staging system for patients with mucosal leishmaniasis
dc.typeArticle


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