Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection

dc.creatorSouza, R. M.
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorLyra, André de Castro
dc.creatorMoraes, C. F.
dc.creatorBraga, Eduardo Lorens
dc.creatorLyra, Luiz Guilherme Costa
dc.date2012-12-10T18:13:16Z
dc.date2012-12-10T18:13:16Z
dc.date2006
dc.date.accessioned2023-09-26T20:49:05Z
dc.date.available2023-09-26T20:49:05Z
dc.identifierSOUZA, R. M. et al. Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection. Brazilian Journal of Medical Biological Researc = Revista Brasileira de Pesquisas Médicas e Biológicas, v. 39, n. 1, p. 79-83, jan. 2006.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5949
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864417
dc.descriptionThe objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy. Liver tissue samples from 95 patients with chronic hepatitis C were divided into two groups: group I, presence of iron overload in hepatic tissue (Perls' staining) and group II, no iron overload. Hepatic iron overload was detected in 30 (31.6 percent) of 95 patients. Of the 69 patients tested by genotyping, 49 (71.01 percent) were genotype 1 and 20 (28.99 percent) genotype non-1. Iron overload was detected in 14 (28.6 percent) patients with genotype 1 and in 6 (30 percent) with genotype non-1 (P = 0.906). There was a significant difference in fibrosis stage between groups (P = 0.005). In group I (N = 30), one patient had stage F0/F1 of fibrosis, while in group II (N = 65), 22 (33.8 percent) patients had minimal or no fibrosis. Fibrosis stage F2/F3 was observed in 70 percent of group I patients compared to 46.2 percent of group II. Eighty-five patients were treated with a combination of interferon and ribavirin; 29 of them (34.1 percent) had a sustained virologic response and 8 (27.6 percent) of them had hepatic iron overload. Iron overload was detected in 18 (32.1 percent) of the 56 non-responders (P = 0.73). Hepatic iron overload was frequent among patients with chronic hepatitis C and was associated with a more severe stage of liver fibrosis. There was no association between iron overload and HCV genotype and response to interferon and ribavirin therapy.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHepatitis C infection
dc.subjectIron overload
dc.subjectGenotype
dc.subjectInflammatory activity
dc.subjectFibrosis
dc.subjectAntiviral therapy
dc.subjectvirina/uso terapêutico
dc.subjectHepatite C Crônica/quimioterapia
dc.subjectHepatite C Crônica/complicações
dc.subjectSobrecarga de Ferro/complicações
dc.subjectInterferon alfa/uso terapêutico
dc.subjectAntivirais/uso terapêutico
dc.subjectHepatite C Crônica/patologia
dc.subjectHepacivirus/genética
dc.subjectHepacivirus/efeitos de drogas
dc.subjectReação em Cadeia da Polimerase
dc.subjectQuimioterapia Combinada
dc.subjectÍndice de Gravidade de Doença
dc.subjectGenótipo
dc.subjectHumanos
dc.subjectMasculino
dc.subjectFeminino
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectMeia-Idade
dc.subjectIdoso
dc.titleEffect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection
dc.typeArticle


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