Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever

dc.creatorMartins, Flaviano dos Santos
dc.creatorAndrade, Samir de Deus Elian
dc.creatorVieira, Angelica Thomaz
dc.creatorTiago, Fabiana da Conceição Pereira
dc.creatorMartins, Ariane Katiuscia dos Santos
dc.creatorSilva, Flávia Cristina de Paula e
dc.creatorSouza, Éricka Lorenna de Sales e
dc.creatorSousa, Lirlândia Pires de
dc.creatorAraújo, Helena Rocha Corrêa de
dc.creatorPimenta, Paulo Filemon Paolucci
dc.creatorBonjardim, Claudio Antonio
dc.creatorArantes, Rosa Maria Esteves
dc.creatorTeixeira, Mauro Martins
dc.creatorNicoli, Jacques Robert
dc.date2014-11-20T16:23:31Z
dc.date2014-11-20T16:23:31Z
dc.date2011
dc.date.accessioned2023-09-26T20:48:46Z
dc.date.available2023-09-26T20:48:46Z
dc.identifierMARTINS, Flaviano dos Santos et al. Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever. International Journal of Medical Microbiology, v. 301, n.4, p. 359-364, 2011.
dc.identifier1438-4221
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8925
dc.identifier10.1016/j.ijmm.2010.11.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864330
dc.descriptionSalmonella spp. is Gram-negative, facultative, intracellular pathogens that cause several diarrheal diseases ranging from self-limiting gastroenteritis to typhoid fever. Previous results from our laboratory showed that Saccharomyces cerevisiae strain UFMG 905 isolated from ‘cachaça’ production presented probiotic properties due to its ability to protect against experimental infection with Salmonella entericaserovar Typhimurium. In this study, the effects of oral treatment with S. cerevisiae 905 were evaluated at the immunological level in a murine model of typhoid fever. Treatment with S. cerevisiae 905 inhibited weight loss and increased survival rate after Salmonella challenge. Immunological data demonstrated that S. cerevisiae 905 decreased levels of proinflammatory cytokines and modulated the activation of mitogen-activated protein kinases (p38 and JNK, but not ERK1/2), NF-κB and AP-1, signaling pathways which are involved in the transcriptional activation of proinflammatory mediators. Experiments in germ-free mice revealed that probiotic effects were due, at least in part, to the binding of Salmonella to the yeast. In conclusion, S. cerevisiae 905 acts as a potential new biotherapy against S. Typhimurium infection due to its ability to bind bacteria and modulate signaling pathways involved in the activation of inflammation in a murine model of typhoid fever.
dc.formatapplication/pdf
dc.languageeng
dc.publisherUrban & Fischer
dc.rightsopen access
dc.subjectProbiotics
dc.subjectSaccharomyces cerevisiae
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectCytokines
dc.subjectMAP kinases
dc.subjectNF-κB
dc.subjectAP-1
dc.titleOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
dc.typeArticle


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