| dc.creator | Silva, Franklin Souza | |
| dc.creator | Nascimento, Samara Braga do | |
| dc.creator | Bourguignon, Saulo Cabral | |
| dc.creator | Pereira, Bernardo Acácio Santini | |
| dc.creator | Carneiro, Paula Fernandes | |
| dc.creator | Silva, Wellington Seguis da | |
| dc.creator | Alves, Carlos Roberto | |
| dc.creator | Pinho, Rosa Teixeira de | |
| dc.date | 2015-05-04T16:34:36Z | |
| dc.date | 2015-05-04T16:34:36Z | |
| dc.date | 2014 | |
| dc.date.accessioned | 2023-09-26T20:48:32Z | |
| dc.date.available | 2023-09-26T20:48:32Z | |
| dc.identifier | SILVA, Franklin Souza et al. Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone. Experimental Parasitology, v.147, p.81–84, 2014. | |
| dc.identifier | 0014-4894 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/10185 | |
| dc.identifier | 10.1016/j.exppara.2014.10.002 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8864266 | |
| dc.description | In this work, we analyze the leishmanicidal effects of epoxy-α-lapachone on Leishmania (Viannia) braziliensis
and Leishmania (Leishmania) amazonensis. Promasigotes and amastigotes (inhabiting human macrophages)
from both species were assayed to verify the compound’s activity over the distinct morphological
stages. The incubation with epoxy-α-lapachone led to a significant decrease in the numbers of promastigotes
from both species in the cultures, in a dose-and time-dependent fashion. The survival of amastigotes inhabiting
human macrophages was also drastically affected by the compound, as shown by the variations
in the endocytic index. Our results indicate that the epoxy-α-lapachone has an antiparasitic effect over
Leishmania in both morphological stages and may potentially affect a range of species in two distinct subgenera
of this parasite. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | restricted access | |
| dc.subject | Leishmania | |
| dc.subject | Naftoquinonas | |
| dc.subject | Leishmania (Viannia) braziliensis | |
| dc.subject | Leishmania (Leishmania) amazonensis | |
| dc.subject | Naphthoquinones | |
| dc.subject | Epoxy-α-lapachone | |
| dc.subject | Leishmania | |
| dc.subject | Naftoquinonas | |
| dc.title | Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone | |
| dc.type | Article | |
