| dc.creator | Vinicius, Igor Di | |
| dc.creator | Baptista, Ana Paula | |
| dc.creator | Barbosa Junior, Aryon de Almeida | |
| dc.creator | Andrade, Zilton de Araújo | |
| dc.date | 2016-03-02T13:59:15Z | |
| dc.date | 2016-03-02T13:59:15Z | |
| dc.date | 2005 | |
| dc.date.accessioned | 2023-09-26T20:48:13Z | |
| dc.date.available | 2023-09-26T20:48:13Z | |
| dc.identifier | VINICIUS, I. di et al. Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats. Pathology, Research and Practice, v. 201, n. 6, p. 449-456, 2005. | |
| dc.identifier | 0344-0338 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/12941 | |
| dc.identifier | 10.1016/j.prp.2005.05.009 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8864179 | |
| dc.description | Regression of hepatic cirrhosis is a controversial issue. Recently, a list of histopathological features, observed in
human material, was suggested as a hallmark of cirrhosis in the process of regression. An investigation for the presence
of these morphologic features was performed at monthly intervals in rats with proved carbon tetrachloride (CCl4)-
induced cirrhosis over a period of 9 months following discontinuation of treatment, using sequential liver biopsies.
Within the first 4 months, features of the ‘‘hepatic repair complex’’ were identified, together with the enlargement of
the hepatic nodules and thinning of the fibrous septa. Subsequent to the 4 months, the histological picture, composed
of large and inconspicuous nodules and delimited by thin and frequently incomplete fibrous septa ‘‘incomplete septal
cirrhosis’’, appeared to be stabilized. These fibrous septa, when injected with India ink from the portal trunk, presented
blood vessels that were seen to drain directly into the sinusoids. These findings suggested that when the cause of
cirrhosis is removed, the liver may adapt itself to a new and permanent structure, probably compatible with normal or
near-normal function, which may render hepatic cirrhosis clinically, although not morphologically, reversible.
r 2005 Elsevier GmbH. All rights reserved. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | open access | |
| dc.subject | Hepatic fibrosis | |
| dc.subject | Cirrhosis | |
| dc.subject | Cirrhosis reversibility | |
| dc.subject | Cirrose Hepática Experimental/patologia | |
| dc.subject | Fígado/patologia | |
| dc.subject | Recuperação de Função Fisiológica | |
| dc.subject | Animais | |
| dc.subject | Marcadores Biológicos/metabolismo | |
| dc.subject | Biópsia | |
| dc.subject | Tetracloreto de Carbono | |
| dc.subject | Modelos Animais de Doenças | |
| dc.subject | Feminino | |
| dc.subject | Imunofluorescência | |
| dc.subject | Hepatócitos/metabolismo | |
| dc.subject | Hidroxiprolina/metabolismo | |
| dc.subject | Cirrose Hepática Experimental/metabolismo | |
| dc.subject | Masculino | |
| dc.title | Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats. | |
| dc.type | Article | |
