Polypeptide with Asparaginase Activity, Expression Cassette, Expression Vector, Host Cell, Pharmaceutical Composition, Methods for Producing a Polypeptide with Asparaginase Activity and for Preventing or Treating Cancer, and Use of a Polypeptide

dc.contributorSouza, Tatiana de Arruda Campos Brasil de
dc.contributorZanchin, Nilson Ivo Tonin
dc.contributorMorais, Stephanie Bath de
dc.date2021-08-31T15:48:01Z
dc.date2021-08-31T15:48:01Z
dc.date2021
dc.date2020-07-17
dc.date.accessioned2023-09-26T20:47:56Z
dc.date.available2023-09-26T20:47:56Z
dc.identifierSOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. US Pat. 2021/0121544 A1, 29 abr. 2021. 31p.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48861
dc.identifierFundação Oswaldo Cruz
dc.identifierA61K 38/50
dc.identifierC12N 15/66
dc.identifierA61P 35/02
dc.identifierUS16/963,173
dc.identifierBR102018001033-6A2
dc.identifierUS2021/0121544A1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864094
dc.descriptionThe present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer.
dc.descriptionBrasil
dc.descriptionOrganização Mundial para Propriedade Intelectual OMPI
dc.descriptionChina
dc.descriptionEscritório de Patentes Europeu
dc.descriptionEstados Unidos da América
dc.descriptionÍndia
dc.descriptionCanadá
dc.formatapplication/pdf
dc.languageeng
dc.publisherUnited States Patent and Trademark Office
dc.rightsopen access
dc.subjectAsparaginase
dc.subjectCâncer
dc.subjectAsparaginase
dc.subjectCancer
dc.titlePolypeptide with Asparaginase Activity, Expression Cassette, Expression Vector, Host Cell, Pharmaceutical Composition, Methods for Producing a Polypeptide with Asparaginase Activity and for Preventing or Treating Cancer, and Use of a Polypeptide
dc.typePatent


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