Experimental surgery of the facial nerve. Assessment of the intraperitoneal use of exogenous gangliosides

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMontovani, Jair Cortez
dc.creatorPrado, R. G.
dc.creatorBacchi, C. E.
dc.date2014-05-27T11:17:59Z
dc.date2016-10-25T18:13:29Z
dc.date2014-05-27T11:17:59Z
dc.date2016-10-25T18:13:29Z
dc.date1995-01-01
dc.date.accessioned2017-04-06T00:45:59Z
dc.date.available2017-04-06T00:45:59Z
dc.identifierRevue de Laryngologie Otologie Rhinologie, v. 116, n. 3, p. 163-167, 1995.
dc.identifier0035-1334
dc.identifierhttp://hdl.handle.net/11449/64585
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64585
dc.identifier2-s2.0-0029082611
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886403
dc.descriptionCompression and section of the facial nerve were performed in 48 rats in order to study the anatomopathological alterations occurring after daily intraperitoneal injections of 100 mg of exogenous gangliosides (Sinaxial®) for 45, 90, 180 days. In groups submitted to nerve compression, the histopathological changes were discrete and in the 180-day subgroups the nerve was practically normal. In animals submitted to section and neurorrhaphy there was formation of an amputation neuroma, a granuloma around the suture, axonal unstructuration and inter and perineural fibrosis. No significant differences were observed between the groups submitted or not to injection of exogenous gangliosides, indicating that the major factors involved in the quality of nerve regeneration were the technique and the formation of fibrosis and of an amputation neuroma.
dc.languageeng
dc.relationRevue de Laryngologie Otologie Rhinologie
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectfacial nerve
dc.subjectgangliosides
dc.subjectganglioside
dc.subjectsinaxial
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectfacial nerve disease
dc.subjecthistopathology
dc.subjectintraperitoneal drug administration
dc.subjectmale
dc.subjectnerve compression
dc.subjectnerve regeneration
dc.subjectnonhuman
dc.subjectrat
dc.subjectanimal
dc.subjectpathology
dc.subjectphysiology
dc.subjectAnimal
dc.subjectEnglish Abstract
dc.subjectFacial Nerve
dc.subjectGangliosides
dc.subjectInjections, Intraperitoneal
dc.subjectMale
dc.subjectNerve Regeneration
dc.subjectRats
dc.titleExperimental surgery of the facial nerve. Assessment of the intraperitoneal use of exogenous gangliosides
dc.typeOtro


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