The role of corticosteroids in severe community-acquired pneumonia: a systematic review

dc.creatorSalluh, Jorge I. F.
dc.creatorPóvoa, Pedro
dc.creatorSoares, Márcio
dc.creatorFaria Neto, Hugo Caire C.
dc.creatorBozza, Fernando A.
dc.creatorBozza, Patrícia T.
dc.date2019-04-04T12:37:41Z
dc.date2019-04-04T12:37:41Z
dc.date2008
dc.date.accessioned2023-09-26T20:47:44Z
dc.date.available2023-09-26T20:47:44Z
dc.identifierSALLUH, Jorge I. F. et al. The role of corticosteroids in severe community-acquired pneumonia: a systematic review. Critical Care, v. 12, n. 3, p. 1-7, 2008.
dc.identifier1364-8535
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32356
dc.identifier10.1186/cc6922
dc.identifier1466-609X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864034
dc.descriptionIntroduction: The purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP). Methods: We performed a systematic MEDLINE, Cochrane database, and CINAHL search (1966 to November 2007) to identify full-text publications that evaluated the use of corticosteroids in CAP. Results: An initial literature search yielded 109 articles, and 105 studies were excluded after the first analysis. We found four studies eligible for analysis. On the basis of their results, the use of corticosteroids as adjunctive therapy in severe CAP should be categorized as a weak recommendation (two studies) and a strong recommendation (two studies) with either low- or moderate-quality evidence. However, no evidence of adverse outcomes or harm is present in the evaluated studies. Conclusion: According to the GRADE system, available studies do not support the recommendation of corticosteroids as a standard of care for patients with severe CAP. Further randomized controlled trials with this aim should enroll a larger number of severely ill patients. However, in patients needing corticosteroids, it may be reasonable to conclude that corticosteroid administration is safe in patients with severe infections receiving antimicrobial therapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMC
dc.rightsopen access
dc.subjectCorticosteróides
dc.subjectPacientes graves
dc.subjectPneumonia
dc.subjectRevisão sistemática
dc.subjectImpacto
dc.subjectAvaliação
dc.subjectCorticosteroids
dc.subjectPneumonia
dc.subjectSevere community-acquired
dc.subjectSystematic review
dc.subjectEvalution
dc.subjectImpact
dc.titleThe role of corticosteroids in severe community-acquired pneumonia: a systematic review
dc.typeArticle


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