Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil

dc.creatorOrnelas, Alice Maria de Magalhães
dc.creatorXavier-de-Carvalho, Caroline
dc.creatorAlvarado-Arnez, Lucia Elena
dc.creatorRibeiro-Alves, Marcelo
dc.creatorRossi, Átila Duque
dc.creatorTanuri, Amilcar
dc.creatorAguiar, Renato Santana
dc.creatorMoraes, Milton Ozório
dc.creatorCardoso, Cynthia Chester
dc.date2019-06-10T19:34:37Z
dc.date2019-06-10T19:34:37Z
dc.date2019
dc.date.accessioned2023-09-26T20:47:37Z
dc.date.available2023-09-26T20:47:37Z
dc.identifierORNELAS, Alice Maria de Magalhães et al. Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33446
dc.identifier10.1590/0074-02760190004
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863997
dc.descriptionBACKGROUND: Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlinedthe association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES: The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS: A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS: No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS: This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz
dc.rightsopen access
dc.subjectDengue
dc.subjectPolymorphisms
dc.subjectMBL2
dc.subjectCCR5
dc.subjectITGB3
dc.subjectCLEC5A
dc.titleAssociation between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
dc.typeArticle


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