Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice

dc.creatorSilva, Tânia Regina Marques da
dc.creatorPetersen, Antonio Luis de Oliveira Almeida
dc.creatorAlmeida, Taís Fontoura de
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorVeras, Patrícia Sampaio Tavares
dc.date2011-03-27T00:54:04Z
dc.date2011-03-27T00:54:04Z
dc.date2010
dc.date.accessioned2023-09-26T20:47:26Z
dc.date.available2023-09-26T20:47:26Z
dc.identifierSILVA, T. R. M. da. et al. Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice. Memórias do Instituto Oswaldo Cruz, v.105, n.5, p. 642-648, 2010.
dc.identifier20835610
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1764
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863939
dc.descriptionMycobacterium fortuitum is a rapidly growing nontuberculous Mycobacterium that can cause a range of diseases in humans. Complications from M. fortuitum infection have been associated with numerous surgical procedures. A protective immune response against pathogenic mycobacterial infections is dependent on the granuloma formation. Within the granuloma, the macrophage effector response can inhibit bacterial replication and mediate the intracellular killing of bacteria. The granulomatous responses of BALB/c mice to rapidly and slowly growing mycobacteria were assessed in vivo and the bacterial loads in spleens and livers from M. fortuitum and Mycobacterium intracellulare-infected mice, as well as the number and size of granulomas in liver sections, were quantified. Bacterial loads were found to be approximately two times lower in M. fortuitum-infected mice than in M. intracellulareinfected mice and M. fortuitum-infected mice presented fewer granulomas compared to M. intracellulare-infected mice. These granulomas were characterized by the presence of Mac-1+ and CD4+ cells. Additionally, IFN-γ mRNA expression was higher in the livers of M. fortuitum-infected mice than in those of M. intracellulare-infected mice. These data clearly show that mice are more capable of controlling an infection with M. fortuitum than M. intracellulare. This capacity is likely related to distinct granuloma formations in mice infected with M. fortuitum but not with M. intracellulare.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectMycobacterium fortuitum
dc.subjectMycobacterium intracellulare
dc.subjectGranuloma
dc.subjectFígado
dc.subjectControle da infeção
dc.subjectGranuloma/PA
dc.subjectFígado/IM
dc.subjectInfecções Atípicas por Mycobacterium/PA
dc.subjectMycobacterium avium/IM
dc.subjectMycobacterium fortuitum/IM
dc.subjectCamundongos Endogâmicos BALB C
dc.titleControl of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice
dc.typeArticle


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