Malaria Related Neurocognitive Deficits and Behavioral Alterations

dc.creatorGonçalves, Pamela Rosa
dc.creatorGomes, Flávia Lima Ribeiro
dc.creatorRibeiro, Cláudio Tadeu Daniel
dc.date2022-06-15T17:43:56Z
dc.date2022-06-15T17:43:56Z
dc.date2022
dc.date.accessioned2023-09-26T20:47:19Z
dc.date.available2023-09-26T20:47:19Z
dc.identifierGONÇALVES, Pamela Rosa et al. Malaria Related Neurocognitive Deficits and Behavioral Alterations. Frontiers in Cellular and Infection Microbiology, v. 12, Article 829413, Feb. 2022.
dc.identifier2235-2988
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53280
dc.identifier10.3389/fcimb.2022.829413
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863904
dc.descriptionTypical of tropical and subtropical regions, malaria is caused by protozoa of the genus Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a major issue of public health. Its clinical course can present either as the classic episodes of fever, sweating, chills and headache or as nonspecific symptoms of acute febrile syndromes and may evolve to severe forms. Survivors of cerebral malaria, the most severe and lethal complication of the disease, might develop neurological, cognitive and behavioral sequelae. This overview discusses the neurocognitive deficits and behavioral alterations resulting from human naturally acquired infections and murine experimental models of malaria. We highlighted recent reports of cognitive and behavioral sequelae of non-severe malaria, the most prevalent clinical form of the disease worldwide. These sequelae have gained more attention in recent years and therapies for them are required and demand advances in the understanding of neuropathogenesis. Recent studies using experimental murine models point to immunomodulation as a potential approach to prevent or revert neurocognitive sequelae of malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectMalária grave
dc.subjectMalária não grave
dc.subjectDéficits neurocognitivos
dc.subjectAlterações comportamentais
dc.subjectMalária murina
dc.subjectSevere malaria
dc.subjectNon-severe malaria
dc.subjectNeurocognitive deficits
dc.subjectBehavioral alterations
dc.subjectMurine malaria
dc.titleMalaria Related Neurocognitive Deficits and Behavioral Alterations
dc.typeArticle


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