Effectiveness of annual single doses of diethylcarbamazine citrate among bancroftian filariasis infected individuals in an endemic area under mass drug administration in Brazil

dc.creatorSilva, Jennifer S. F. da
dc.creatorBraga, Cynthia
dc.creatorDuarte, Felipe M.
dc.creatorOliveira, Paula
dc.creatorLuna, Carlos Feitosa
dc.creatorMarcondes, Márcia
dc.creatorAraújo, Josué
dc.creatorGrilis, Maria Rosangela
dc.creatorMelo, Paula Fernanda A. de Souza
dc.creatorBrandão, Eduardo
dc.creatorRocha, Abraham
dc.date2019-11-08T14:15:53Z
dc.date2019-11-08T14:15:53Z
dc.date2018
dc.date.accessioned2023-09-26T20:47:03Z
dc.date.available2023-09-26T20:47:03Z
dc.identifierSILVA, J. S. F. da et al. Effectiveness of annual single doses of diethylcarbamazine citrate among bancroftian filariasis infected individuals in an endemic area under mass drug administration in Brazil. Pathogens and Global Health, v. 112, n. 5, p. 274–280, 2018.
dc.identifier2047-7724
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36958
dc.identifier10.1080/20477724.2018.1498821
dc.identifier2047-7724
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863818
dc.descriptionSecretaria de Vigilância em Saúde / Fundação Oswaldo Cruz / Fundação para o Desenvolvimento Tecnológico em Saúde
dc.descriptionThe Global Program to Eliminate Lymphatic Filariasis has achieved extraordinary success in reducing transmission and preventing morbidity through mass drug administration (MDA) to the population at-risk. Brazil is the only currently using diethylcarbamazine citrate (DEC) alone for MDA, so an assessment of its effectiveness is needed. We report the trends of filarial markers in a cohort of 175 individuals infected with Wuchereria bancrofti in areas that underwent MDA in the city of Olinda, Northeastern Brazil. The prospective study was conducted between 2007 and 2012 (corresponding to five annual MDA rounds). The quantification of microfilaraemia (QMFF) was assessed by filtration. Circulating filarial antigen (CFA) was detected through immunochromatographic point-of-care test (POCT-ICT) and Og4C3-ELISA whereas antifilarial antibody titres (IgG4) were assessed through Bm14 assay. The CFA and IgG4 titres were measured by Optical Density (OD). The main characteristics at baseline, MDA coverage and the trend of filarial infection markers during follow up were described. The trend of filarial markers in relation to time (years of MDA), sex and age were analysed through Generalized Estimating Equations (GEE) models. The models demonstrated a significant decrease in all markers during MDA. The probability of remaining positive by QMFF and POCT-ICT diminished 70% and 46%, respectively, after each MDA round. There was a significant annual drop in CFA (-0.290 OD) and IgG4 antibodies titres (-0.303 OD). This study provides evidence that MDA with DEC alone can be effective in the elimination of LF in Brazil.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectLymphatic filariasis
dc.subjectWuchereria bancrofti
dc.subjectDiethylcarbamazine citrate
dc.subjectMass drug administration
dc.subjectPrevention and control
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAnimais
dc.subjectAnticorpos Anti-Helmínticos / sangue
dc.subjectAntígenos de Helmintos / sangue
dc.subjectBrasil / epidemiologia
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectTestes Diagnósticos de Rotina
dc.subjectDietilcarbamazina / administração & dosagem
dc.subjectTransmissão de Doença Infecciosa / prevenção & controle
dc.subjectFilariose Linfática / tratamento farmacológico
dc.subjectFilariose Linfática / epidemiologia
dc.subjectFilariose Linfática / prevenção & controle
dc.subjectDoenças Endêmicas
dc.subjectFeminino
dc.subjectFilaricidas / administração & dosagem
dc.subjectSeguimentos
dc.subjectHumanos
dc.subjectMasculino
dc.subjectAdministração Massiva de Medicamentos / métodos
dc.subjectPessoa de Meia-Idade
dc.subjectCarga Parasitária
dc.subjectEstudos Prospectivos
dc.subjectResultado do Tratamento
dc.subjectWuchereria bancrofti / efeitos dos fármacos
dc.subjectAdulto Jovem
dc.titleEffectiveness of annual single doses of diethylcarbamazine citrate among bancroftian filariasis infected individuals in an endemic area under mass drug administration in Brazil
dc.typeArticle


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