dc.creator | Duarte, Fernanda Gross | |
dc.creator | Barberino, Maria Goreth | |
dc.creator | Moreira, Sandra da Silva | |
dc.creator | Reis, Joice Neves | |
dc.creator | Spinardi, Julia Regazzini | |
dc.creator | Almeida, Rodrigo Sini de | |
dc.creator | Allen, Kristen E | |
dc.creator | Parrish, Ronika Alexander | |
dc.creator | Brim, Rosa | |
dc.creator | Araújo Neto, César Augusto de | |
dc.creator | Moreira, Edson Duarte | |
dc.date | 2022-05-06T18:40:36Z | |
dc.date | 2022-05-06T18:40:36Z | |
dc.date | 2022 | |
dc.date.accessioned | 2023-09-26T20:46:58Z | |
dc.date.available | 2023-09-26T20:46:58Z | |
dc.identifier | DUARTE, Fernanda Gross et al. Incidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil. BMJ Open, v. 12, n. 4, p. 1-11, 2022. | |
dc.identifier | 2044-6055 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/52570 | |
dc.identifier | 10.1136/bmjopen-2021-059824. | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8863791 | |
dc.description | Pfizer, São Paulo, Brasil. Associação Obras Sociais Irmã Dulce e Pfizer. | |
dc.description | Objectives: To determine the incidence, aetiology and pneumococcal serotype distribution of community-acquired pneumonia (CAP) in Brazilian adults during a 2-year period. Design: Prospective population-based surveillance study. Setting: Patients from two emergency hospitals in Brazil were consecutively included in this study. Participants: A total of 111 adults aged 50 years and older with radiographically-confirmed CAP requiring an emergency department visit were prospectively enrolled between January 2018 and January 2020.
Main outcome measures: Incidence rates of CAP were calculated according to age and pathogen. Pathogens were identified by conventional microbiological methods. Additionally, a novel, Luminex-based serotype specific urinary antigen detection assay was used to detect serotypes included in pneumococcal vaccines.
Results: Mean age of participants was 64 years and 31% were aged ≥70 years. Aetiology was established in 61 (57%) patients; among identified cases, the most common pathogens were Streptococcus pneumoniae (42/61, 69%) and influenza (4/61, 7%). Among serotypes identified from the 42 cases of pneumococcal CAP, estimated coverage ranged by pneumococcal vaccine formulations from 47.6% (13-valent), 59.5% (20-valent, licenced in the USA only) and 71.4% (23-valent). In patients with CAP, 20-valent pneumococcal vaccine serotypes were identified 2.5 times more frequently than 10-valent pneumococcal vaccine serotypes (22.5% vs 9.0%). The incidence rate for CAP in adults aged ≥50 years was 20.1 per 10 000 person-years. In general, the incidence of CAP increased consistently with age, reaching 54.4 (95% CI 36.8 to -76.6) per 10 000 in adults 80 years or older. Conclusions: We observed a high burden of pneumococcal CAP among adults in Brazil. Despite the routine immunisation of children and high-risk adults against pneumococcal disease in the Brazilian national vaccination programme, a persistent burden of pneumococcal CAP caused by vaccine serotypes remains in this population. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | BMJ Publishing Group | |
dc.rights | open access | |
dc.subject | Pneumonia | |
dc.subject | Streptococcus pneumoniae | |
dc.subject | Pneumonia adquirida na comunidade | |
dc.subject | Incidência | |
dc.subject | Vacinas pneumocócicas | |
dc.subject | Distribuição de sorotipos | |
dc.subject | Streptococcus pneumoniae | |
dc.subject | Community-acquired pneumonia | |
dc.subject | Incidence | |
dc.subject | Pneumococcal vaccines | |
dc.subject | Serotype distribution | |
dc.subject | Streptococcus pneumoniae | |
dc.subject | Pneumonia | |
dc.subject | Incidência | |
dc.subject | Vacinas Pneumocócicas | |
dc.subject | Streptococcus pneumoniae | |
dc.title | Incidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil | |
dc.type | Article | |