dc.creatorDuarte, Fernanda Gross
dc.creatorBarberino, Maria Goreth
dc.creatorMoreira, Sandra da Silva
dc.creatorReis, Joice Neves
dc.creatorSpinardi, Julia Regazzini
dc.creatorAlmeida, Rodrigo Sini de
dc.creatorAllen, Kristen E
dc.creatorParrish, Ronika Alexander
dc.creatorBrim, Rosa
dc.creatorAraújo Neto, César Augusto de
dc.creatorMoreira, Edson Duarte
dc.date2022-05-06T18:40:36Z
dc.date2022-05-06T18:40:36Z
dc.date2022
dc.date.accessioned2023-09-26T20:46:58Z
dc.date.available2023-09-26T20:46:58Z
dc.identifierDUARTE, Fernanda Gross et al. Incidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil. BMJ Open, v. 12, n. 4, p. 1-11, 2022.
dc.identifier2044-6055
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/52570
dc.identifier10.1136/bmjopen-2021-059824.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863791
dc.descriptionPfizer, São Paulo, Brasil. Associação Obras Sociais Irmã Dulce e Pfizer.
dc.descriptionObjectives: To determine the incidence, aetiology and pneumococcal serotype distribution of community-acquired pneumonia (CAP) in Brazilian adults during a 2-year period. Design: Prospective population-based surveillance study. Setting: Patients from two emergency hospitals in Brazil were consecutively included in this study. Participants: A total of 111 adults aged 50 years and older with radiographically-confirmed CAP requiring an emergency department visit were prospectively enrolled between January 2018 and January 2020. Main outcome measures: Incidence rates of CAP were calculated according to age and pathogen. Pathogens were identified by conventional microbiological methods. Additionally, a novel, Luminex-based serotype specific urinary antigen detection assay was used to detect serotypes included in pneumococcal vaccines. Results: Mean age of participants was 64 years and 31% were aged ≥70 years. Aetiology was established in 61 (57%) patients; among identified cases, the most common pathogens were Streptococcus pneumoniae (42/61, 69%) and influenza (4/61, 7%). Among serotypes identified from the 42 cases of pneumococcal CAP, estimated coverage ranged by pneumococcal vaccine formulations from 47.6% (13-valent), 59.5% (20-valent, licenced in the USA only) and 71.4% (23-valent). In patients with CAP, 20-valent pneumococcal vaccine serotypes were identified 2.5 times more frequently than 10-valent pneumococcal vaccine serotypes (22.5% vs 9.0%). The incidence rate for CAP in adults aged ≥50 years was 20.1 per 10 000 person-years. In general, the incidence of CAP increased consistently with age, reaching 54.4 (95% CI 36.8 to -76.6) per 10 000 in adults 80 years or older. Conclusions: We observed a high burden of pneumococcal CAP among adults in Brazil. Despite the routine immunisation of children and high-risk adults against pneumococcal disease in the Brazilian national vaccination programme, a persistent burden of pneumococcal CAP caused by vaccine serotypes remains in this population.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBMJ Publishing Group
dc.rightsopen access
dc.subjectPneumonia
dc.subjectStreptococcus pneumoniae
dc.subjectPneumonia adquirida na comunidade
dc.subjectIncidência
dc.subjectVacinas pneumocócicas
dc.subjectDistribuição de sorotipos
dc.subjectStreptococcus pneumoniae
dc.subjectCommunity-acquired pneumonia
dc.subjectIncidence
dc.subjectPneumococcal vaccines
dc.subjectSerotype distribution
dc.subjectStreptococcus pneumoniae
dc.subjectPneumonia
dc.subjectIncidência
dc.subjectVacinas Pneumocócicas
dc.subjectStreptococcus pneumoniae
dc.titleIncidence, aetiology and serotype coverage for pneumococcal vaccines of community-acquired pneumonia in adults: a population-based prospective active surveillance study in Brazil
dc.typeArticle


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