| dc.creator | Sleigh, A. C | |
| dc.creator | Mott, K. E | |
| dc.creator | Hoff, R | |
| dc.creator | Barreto, Maurício Lima | |
| dc.creator | Mota, E. A | |
| dc.creator | Maguire, J. H | |
| dc.creator | Sherlock, Ítalo Rodrigues de Araújo | |
| dc.creator | Weller, T. H | |
| dc.date | 2016-08-12T12:31:06Z | |
| dc.date | 2016-08-12T12:31:06Z | |
| dc.date | 1985 | |
| dc.date.accessioned | 2023-09-26T20:46:55Z | |
| dc.date.available | 2023-09-26T20:46:55Z | |
| dc.identifier | SLEIGH, A. C. et al. Three-year prospective study of the evolution of Manson’s Schistosomiasis in North-East Brazil. The Lancet, p. 63-66, 1985. | |
| dc.identifier | 0140-6736 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/15249 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8863777 | |
| dc.description | A cross-sectional study of morbidity
associated with Schistosoma mansoni
infection in an area in North-East Brazil where the disease is
endemic was carried out in 1974. The survey was repeated in
1977, before mass treatment with oxamniquine, providing a
cohort of 210 individuals who had both examinations. The
high prevalence of hepatomegaly (over 80%) and of
splenomegaly (over 15%) contrasted with rates of 10% and
1%, respectively, in a non-endemic area. Over the 3-year
period hepatomegaly spontaneously regressed in 13% of
patients, and splenomegaly regressed in 56%, a phenomenon
most common in older individuals with light infections.
Those with heavy infections—ie, 500 or more eggs per g
faeces, had an excess risk of splenomegaly of 19·6% and, of
its persistence, of 61· 5%. Thus, intensity of infection was a
critical factor in liver and spleen involvement, and
programmes of chemotherapy that reduce infection should
mitigate the risk of schistosomal morbidity. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | open access | |
| dc.subject | Schistosomiasis mansoni | |
| dc.subject | Oxamniquine | |
| dc.subject | Schistosomiasis | |
| dc.subject | Hepatomegaly | |
| dc.subject | Splenomegaly | |
| dc.subject | Cross-Sectional Studies | |
| dc.subject | Liver | |
| dc.subject | Brazil | |
| dc.subject | Humans | |
| dc.subject | Prevalence | |
| dc.title | Three-year prospective study of the evolution of Manson’s Schistosomiasis in North-East Brazil | |
| dc.type | Article | |
