Angiogenesis and schistosomiasis

dc.creatorAndrade, Zilton de Araújo
dc.creatorSantana, Thayna Souto
dc.date2011-03-29T14:40:56Z
dc.date2011-03-29T14:40:56Z
dc.date2010
dc.date.accessioned2023-09-26T20:46:53Z
dc.date.available2023-09-26T20:46:53Z
dc.identifierANDRADE, Z. A.; SANTANA, T. S. Angiogenesis and schistosomiasis. Memórias do Instituto Oswaldo Cruz, v. 105, n. 5, p. 436-439, 2010.
dc.identifier0074-0216
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1789
dc.identifier10.1590/S0074-02762010000400013
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863761
dc.descriptionAngiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vessels, accompanied by production of vascular-endothelial growth factor, appeared prominent during fibrosis regression months after curative treatment of schistosomiasis. Thus, angiogenesis in schistosomiasis seems to have a two-way mode of action, participating both in fibrogenesis and in fibrosis degradation. Morphological observations presented here are in keeping with the possibility that, in the first case, angiogenesis allows pericytes to come in great numbers to the site of lesions and be detached from capillary walls and transformed into myofibroblasts, which are important extra-cellular matrix forming cells. During post-curative fibrosis regression, actin-containing pericytes appeared at various foci of tissue remodelling, especially at sites of repair of vascular lesions. The molecular and cell factors involved in both situations seem to be important subjects in need of further investigations and the schistosomiasis model certainly will be of great avail in this regard.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectAngiogenese
dc.subjectFibrose hepatica
dc.subjectPericitos
dc.subjectAngiogenesis
dc.subjectPericytes
dc.subjectHepatic fibrosis
dc.subjectRemodelling
dc.subjectCirrose Hepática/PS
dc.subjectNeovascularização Patológica
dc.subjectEsquistossomose mansoni
dc.subjectGranuloma/PS
dc.titleAngiogenesis and schistosomiasis
dc.typeArticle


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