Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax

dc.creatorCassiano, Gustavo Capatti
dc.creatorFurini, Adriana Antonia Cruz
dc.creatorCapobianco, Marcela Petrolini
dc.creatorMelo, Luciane Moreno Storti
dc.creatorCunha, Maristela Gomes da
dc.creatorKano, Flora Satiko
dc.creatorCarvalho, Luzia Helena
dc.creatorSoares, Irene da Silva
dc.creatorSantos, Sidney Emanuel Batista dos
dc.creatorPóvoa, Marinete Marins
dc.creatorMachado, Ricardo Luiz Dantas
dc.date2016-07-20T17:49:33Z
dc.date2016-07-20T17:49:33Z
dc.date2016
dc.date.accessioned2023-09-26T20:46:46Z
dc.date.available2023-09-26T20:46:46Z
dc.identifierCassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 2016
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15010
dc.identifier10.1371/journal.pone.0149581
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863723
dc.descriptionThe development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectAntibodies, Protozoan/immunology
dc.subjectAntigens, CD/genetics
dc.subjectAntigens, CD/immunology
dc.subjectImmunoglobulin G/immunology
dc.subjectMalaria, Vivax/genetics
dc.subjectMalaria, Vivax/immunology
dc.titlePolymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
dc.typeArticle


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