Change in COVID-19 risk over time following vaccination with CoronaVac: a testnegative case-control study

dc.creatorHitchings, Matt D. T.
dc.creatorRanzani, Otavio T.
dc.creatorLind, Margaret L.
dc.creatorDorion, Murilo
dc.creatorD’Agostini, Tatiana Lang
dc.creatorPaula, Regiane Cardoso de
dc.creatorPaula, Olivia Ferreira Pereira de
dc.creatorVillela, Edlaine Faria de Moura
dc.creatorTorres, Mario Sergio Scaramuzzini
dc.creatorOliveira, Silvano Barbosa de
dc.creatorSchulz, Wade
dc.creatorAlmiron, Maria
dc.creatorSaid, Rodrigo
dc.creatorOliveira, Roberto Dias de
dc.creatorSilva, Patricia Vieira da
dc.creatorAraújo, Wildo Navegantes de
dc.creatorGorinchteyn, Jean Carlo
dc.creatorDean, Natalie E.
dc.creatorAndrews, Jason R.
dc.creatorCummings, Derek A. T.
dc.creatorKo, Albert I.
dc.creatorCroda, Julio
dc.date2022-02-14T12:47:12Z
dc.date2022-02-14T12:47:12Z
dc.date2021
dc.date.accessioned2023-09-26T20:46:25Z
dc.date.available2023-09-26T20:46:25Z
dc.identifierHITCHINGS, Matt D. T. et.al. Change in COVID-19 risk over time following vaccination with CoronaVac: a testnegative case-control study. MedRxiv preprint, p. 1-23, 2021.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51167
dc.identifier10.1101/2021.12.23.21268335
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863626
dc.descriptionInstituto Nacional de Alergia e Doenças Infecciosas para N.E.D.
dc.descriptionObjective To estimate the change in odds of covid-19 over time following primary series completion of the inactivated whole virus vaccine, CoronaVac (Sinovac Biotech) in São Paulo state, Brazil. Design Test negative case-control study. Setting Community testing for covid-19 in São Paulo state, Brazil. Participants Adults aged 18-120 years who were residents of São Paulo state, without a previous laboratory-confirmed covid-19 infection, who received only two doses of CoronaVac, and underwent reverse transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 from 17 January to 30 September 2021. Main outcome measures RT-PCR-confirmed symptomatic covid-19 and associated hospital admissions and deaths. Cases were pair-matched to test-negative controls by age (in 5-year bands), municipality of residence, healthcare worker (HCW) status, and date of RT-PCR test (±3 days). Conditional logistic regression was adjusted for sex, number of covid-19-associated comorbidities, race, and previous acute respiratory infection. Results From 137,820 eligible individuals, 37,929 cases with symptomatic covid-19 and 25,756 testnegative controls with covid-19 symptoms were formed into 37,929 matched pairs. Adjusted odds ratios of symptomatic covid-19 increased with time since series completion, and this increase was greater in younger individuals, and among HCWs compared to non-HCWs. Adjusted odds ratios of covid-19 hospitalisation or death were significantly increased from 98 days since series completion, compared to individuals vaccinated 14-41 days previously: 1.40 (95% confidence interval 1.09 to 1.79) from 98-125 days, 1.55 (1.16 to 2.07) from 126-153 days, 1.56 (1.12 to 2.18) from 154-181 days, and 2.12 (1.39-3.22) from 182 days. Conclusions In the general population of São Paulo state, Brazil, an increase in odds of moderate and severe covid-19 outcomes was observed over time following primary series completion with CoronaVac.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMedRxiv
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectCoronaVac
dc.subjectVacinas
dc.subjectVacinas de Produtos Inativados
dc.subjectEstudos de Casos e Controles
dc.subjectBrasil
dc.subjectCOVID-19
dc.subjectCoronaVac
dc.subjectVaccines
dc.subjectVaccines, Inactivated
dc.subjectCase-Control Studies
dc.subjectBrazil
dc.titleChange in COVID-19 risk over time following vaccination with CoronaVac: a testnegative case-control study
dc.typePreprint


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