Simvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage

dc.creatorCampos, Laise M.
dc.creatorGuapyassu, Livia
dc.creatorGomes, Cyro
dc.creatorMidlej, Victor
dc.creatorBenchimol, Marlene
dc.creatorMermelstein, Claudia
dc.creatorCosta, Manoel Luis
dc.date2022-03-17T19:13:59Z
dc.date2022-03-17T19:13:59Z
dc.date2022
dc.date.accessioned2023-09-26T20:46:15Z
dc.date.available2023-09-26T20:46:15Z
dc.identifierCAMPOS, Laise M. et al. Simvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage. Frontiers in Cell and Developmental Biology, v. 10, Article 778901, p. 1 - 7, Mar. 2022.
dc.identifier2296-634X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51729
dc.identifier10.3389/fcell.2022.778901
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863578
dc.descriptionSimvastatin is one of the most common medicines prescribed to treat human hypercholesterolemia. Simvastatin acts through the inhibition of cholesterol synthesis. Unfortunately, simvastatin causes unwanted side effects on muscles, such as soreness, tiredness, or weakness. Therefore, to understand the mechanism of action of simvastatin, it is important to study its physiological and structural impacts on muscle in varied animal models. Here we report on the effects of simvastatin on two biological models: zebrafish embryos and chicken muscle culture. In the last years, our group and others showed that simvastatin treatment in zebrafish embryos reduces fish movements and induces major structural alterations in skeletal muscles. We also showed that simvastatin and membrane cholesterol depletion induce major changes in proliferation and differentiation of muscle cells in chick muscle cultures. Here, we review and discuss these observations considering reported data on the use of simvastatin as a potential therapy for Duchenne muscular dystrophy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectSinvastatina
dc.subjectMúsculo
dc.subjectColesterol
dc.subjectEmbrião
dc.subjectPeixe-zebra
dc.subjectSimvastatin
dc.subjectMuscle
dc.subjectCholesterol
dc.subjectEmbryo
dc.subjectZebrafish
dc.titleSimvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage
dc.typeArticle


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