Leukocyte lipid bodies - Biogenesis and functions in inflammation

dc.creatorBozza, Patrícia T.
dc.creatorMagalhães, Kelly G.
dc.creatorWeller, Peter F.
dc.date2018-09-23T16:01:15Z
dc.date2018-09-23T16:01:15Z
dc.date2009
dc.date.accessioned2023-09-26T20:46:12Z
dc.date.available2023-09-26T20:46:12Z
dc.identifierBOZZA, Patricia T.; MAGALHÃES, Kelly G.; WELLER, Peter F. Leukocyte lipid bodies - biogenesis and functions in inflammation, Biochim Biophys Acta, v.1791, n.6, p.540–551, June 2009.
dc.identifier0006-3002
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29002
dc.identifier10.1016/j.bbalip.2009.01.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863560
dc.descriptionLipid body accumulation within leukocytes is a common feature in both clinical and experimental infectious, neoplasic and other inflammatory conditions. Here, we will review the contemporary evidence related to the biogenesis and structure of leukocyte lipid bodies (also known as lipid droplets) as inflammatory organelles. Studies of leukocyte lipid bodies are providing functional, ultrastructural and protein compositional evidences that lipid bodies are not solely storage depots of neutral lipid. Over the past years substantial progresses have been made to demonstrate that lipid body biogenesis is a highly regulated process, that culminate in the compartmentalization of a specific set of proteins and lipids, that place leukocyte lipid bodies as inducible cytoplasmic organelles with roles in cell signaling and activation, regulation of lipid metabolism, membrane trafficking and control of the synthesis and secretion of inflammatory mediators. Pertinent to the roles of lipid bodies in inflammation and cell signaling, enzymes involved in eicosanoid synthesis are localized at lipid bodies and lipid bodies are sites for eicosanoid generation. Collectively, lipid bodies in leukocytes are emerging as critical regulators of different inflammatory diseases, key markers of leukocyte activation and attractive targets for novel anti-inflammatory therapies.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectLeucócitos
dc.subjectEicosanoides
dc.subjectCélulas Espumosas
dc.subjectLipid droplets
dc.subjectInflammation
dc.subjectfoam cells
dc.subjecteicosanoids
dc.subjectleukocytes
dc.subjecteosinophils
dc.subjectneutrophils
dc.subjectEosinófilos
dc.subjectNeutrófilos
dc.subjectGotículas Lipídicas
dc.titleLeukocyte lipid bodies - Biogenesis and functions in inflammation
dc.typeArticle


Este ítem pertenece a la siguiente institución