Results from the clinical trial of uniform multidrug therapy for Leprosy patients in Brazil (U-MDT/CT-BR): decrease in bacteriological index

dc.creatorPenna, Maria Lucia Fernandes
dc.creatorBührer-Sékula, Samira
dc.creatorPontes, Maria Araci de Andrade
dc.creatorCruz, Rossilene
dc.creatorGonçalves, Heitor de Sá
dc.creatorPenna, Gerson Oliveira
dc.date2020-05-20T17:10:44Z
dc.date2020-05-20T17:10:44Z
dc.date2014
dc.date.accessioned2023-09-26T20:46:09Z
dc.date.available2023-09-26T20:46:09Z
dc.identifierPENNA, Maria Lucia Fernandes et al. Results from the clinical trial of uniform multidrug therapy for Leprosy Patients in Brazil (U-MDT/CT-BR): decrease in bacteriological index. Leprosy Review, [London], v. 85, p. 262-266, 2014.
dc.identifier0305-7518
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41332
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863544
dc.descriptionGerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
dc.descriptionBackground: Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control. Objective: To evaluate the association between treatment duration and the trend in bacteriological index (BI) decrease over time among patients given Uniform MDT (UMDT) compared to those given regular MDT (RMDT). Methods: An open-label randomised clinical trial to compare the present routine treatment with one lasting six month. Patient intake was from March 2007 to February 2012. To evaluate the trend of BI as a function of time, a multilevel linear with mixed effects model was fixed to the two study groups and also four groups after stratification by BI, less than 3 and 3 or more. Results: The BI fall was higher among those taking RMDT, this difference however was not statistically significant. Conclusion: The results presented here support the possibility of use of UMDT in the field, but further follow up is still needed for a final conclusion.
dc.description2050-12-31
dc.formatapplication/pdf
dc.languageeng
dc.publisherBritish Leprosy Relief Association
dc.rightsrestricted access
dc.subjectLeprosy
dc.subjectBacterial load
dc.subjectDrug Therapy, Combination
dc.subjectFollow-Up Studies
dc.subjectLeprostatic Agents
dc.subjectMycobacterium leprae
dc.subjectRegression Analysis
dc.subjectLeprosy, Multibacillary
dc.subjectBrazil
dc.subjectLeprosy
dc.subjectLeprostatic agents
dc.subjectMultibacillary Leprosy
dc.subjectDrug therapy
dc.subjectMycobacterium leprae
dc.subjectHanseníase
dc.subjectMycobacterium leprae
dc.subjectHansenostáticos
dc.titleResults from the clinical trial of uniform multidrug therapy for Leprosy patients in Brazil (U-MDT/CT-BR): decrease in bacteriological index
dc.typeArticle


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