Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals

dc.creatorBrito, Carlos Alexandre Antunes de
dc.creatorMarques, Claudia Diniz Lopes
dc.creatorFrança, Rafael Freitas de Oliveira
dc.creatorMonteiro, Janaína Gomes Ratis
dc.creatorBrito, Marina Coelho Moraes de
dc.creatorLopes, Fabiana
dc.creatorLima, Anton
dc.creatorMarques, Gabriel L.
dc.creatorValadares, Maria Luisa David de Azevedo
dc.creatorDuarte, Angela Luzia Branco Pinto
dc.date2020-12-29T14:17:44Z
dc.date2020-12-29T14:17:44Z
dc.date2020
dc.date.accessioned2023-09-26T20:45:59Z
dc.date.available2023-09-26T20:45:59Z
dc.identifierBRITO, Carlos Alexandre Antunes de et al. Reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals. Journal of Tropical Medicine, v. 2020, p. 1-6, 10 Jul. 2020.
dc.identifier1687-9686
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45462
dc.identifier10.1155/2020/2071325
dc.identifier1687-9694
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863493
dc.descriptionChikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p = 0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p = 0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group (p = 0.021), maintaining a statistically significant difference only for users of anti-TNF. This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls. This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi
dc.rightsopen access
dc.subjectChikungunya fever
dc.subjectChronic symptoms
dc.subjectMusculoskeletal pain
dc.subjectAutoimmune inflammatory disease
dc.titleReduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals
dc.typeArticle


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