Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy

dc.creatorLobo, Iza Maria Fraga
dc.creatorSoares, Milena Botelho Pereira
dc.creatorCorreia, Tania Maria
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorOliveira, Maria Ines
dc.creatorNakatani, Maria
dc.creatorMartins Netto, Eduardo
dc.creatorBadaró, Roberto José da Silva
dc.creatorDavid, John R
dc.date2015-04-16T13:17:49Z
dc.date2015-04-16T13:17:49Z
dc.date2006
dc.date.accessioned2023-09-26T20:45:25Z
dc.date.available2023-09-26T20:45:25Z
dc.identifierLOBO, I. M. F. et al. Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 100, n. 7, p. 642—649, 2006.
dc.identifier0035-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10023
dc.identifier10.1016/j.trstmh.2005.08.011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863318
dc.descriptionControlled heat delivered as radio waves has been used successfully in the treatment of cutaneous leishmaniasis (CL). Here we investigated whether local heat therapy has systemic effects, as measured by the modulation of cytokine production following heat therapy of CL lesions compared with antimonial (Glucantime) treatment. Patients with CL were randomly assigned into this study. Heat (50 degrees C for 30s) was applied once. The control group received Glucantime therapy for 20 d. Cytokine production by peripheral blood mononuclear cells was assayed on days 0, 14 and 28 after onset of treatment. At the end of 28 d, 75% of lesions were healing or healed in the heat therapy group and 90% in the control group (P=0.1261). There was a decrease in IFN-gamma, IL-5 and TNF-alpha levels comparing day 0 with day 28 in both groups, but no difference between the two therapy groups. In patients with only one of several lesions treated with heat therapy, the untreated lesions also healed. Local heat therapy in CL lesions leads to systemic cytokine responses similar to that induced by systemic Glucantime therapy
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectLeishmaniasis Cutaneous
dc.subjectLeishmaniasis
dc.subjectHeat therapy
dc.subjectCytokine
dc.subjectBrazil
dc.subjectAntiprotozoários/uso terapêutico
dc.subjectCitocinas/metabolismo
dc.subjectTemperatura Alta/uso terapêutico
dc.subjectLeishmaniose Cutânea/terapia
dc.subjectMeglumina/uso terapêutico
dc.subjectCompostos Organometálicos/uso terapêutico
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectFeminino
dc.subjectHumanos
dc.subjectInterferon gama/metabolismo
dc.subjectInterleucina-10/metabolismo
dc.subjectLeishmaniose Cutânea/quimioterapia
dc.subjectLeucócitos Mononucleares/imunologia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectResultado do Tratamento
dc.subjectFator de Necrose Tumoral alfa/metabolismo
dc.titleHeat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
dc.typeArticle


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