Increased oxygen radical and high-dietary-carbohydrate pancreatic damage.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNovelli, E. L.
dc.creatorNovelli Filho, J. L.
dc.creatorRodrigues, N. L.
dc.creatorRibas, B. O.
dc.date2014-05-27T11:17:56Z
dc.date2016-10-25T18:13:17Z
dc.date2014-05-27T11:17:56Z
dc.date2016-10-25T18:13:17Z
dc.date1994-01-01
dc.date.accessioned2017-04-06T00:45:12Z
dc.date.available2017-04-06T00:45:12Z
dc.identifierBoletin de estudios medicos y biologicos, v. 42, n. 1-4, p. 21-25, 1994.
dc.identifier0067-9666
dc.identifierhttp://hdl.handle.net/11449/64459
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64459
dc.identifier2-s2.0-0028367698
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886305
dc.descriptionThese data suggest that an improved understanding of the relationship between high dietary carbohydrate and the rate of lipid peroxidation may give some insight into possible treatment modalities for pancreatic damages and may shed light on molecular mechanisms underlying certain pathological processes. High dietary carbohydrate lesions are age related and induced alterations on ceruloplasmin, phospholipids, total proteins, copper and zinc serum levels. Significantly increased serum and pancreatic amylase, and lipoperoxide determinations were observed in 20 month old rats. Cu-Zn superoxide dismutase was decreased in these animals. Daily injection of Cu-Zn superoxide dismutase conjugated with polyethylene glycol (SOD-PEG) prevented the serum and pancreatic changes, indicating that superoxide radical is an important intermediate to high dietary carbohydrate lesion.
dc.languageeng
dc.relationBoletin de estudios medicos y biologicos
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmacrogol derivative
dc.subjectreactive oxygen metabolite
dc.subjectsuperoxide dismutase
dc.subjectanimal
dc.subjectcarbohydrate diet
dc.subjectenzymology
dc.subjectmetabolism
dc.subjectpancreas disease
dc.subjectrat
dc.subjectrat strain
dc.subjectAnimal
dc.subjectDietary Carbohydrates
dc.subjectPancreatic Diseases
dc.subjectPolyethylene Glycols
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReactive Oxygen Species
dc.subjectSuperoxide Dismutase
dc.subjectSupport, Non-U.S. Gov't
dc.titleIncreased oxygen radical and high-dietary-carbohydrate pancreatic damage.
dc.typeOtro


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