Transporte jejunal eletrogênico da glicose em ratos com deficiência de niacina.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVictoria, C. R.
dc.date2014-05-27T11:17:55Z
dc.date2016-10-25T18:13:16Z
dc.date2014-05-27T11:17:55Z
dc.date2016-10-25T18:13:16Z
dc.date1994-01-01
dc.date.accessioned2017-04-06T00:45:10Z
dc.date.available2017-04-06T00:45:10Z
dc.identifierArquivos de Gastroenterologia, v. 31, n. 1, p. 18-23, 1994.
dc.identifier0004-2803
dc.identifierhttp://hdl.handle.net/11449/64454
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64454
dc.identifier2-s2.0-0028185470
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886300
dc.descriptionThe active electrogenic absorption of glucose was studied in 12 niacin deficient rats using a method for measuring changes in transmural potential difference across jejunal mucosa. The glucose was infused in 6 different concentrations (2.5; 5.0; 10.0; 20.0; 50.0 and 100.0 mM/L) at a constant rate of 1.7 ml per minute. The apparent kinetic parameters (Km and Pdmax) of active electrogenic transport were obtained graphically from curves of glucose transfer potentials. The results were compared with that obtained in a control group. The curve of glucose transfer potential in niacin deficient group was significantly lower than that of the control group. The apparent Km of niacin deficient group was greater than in the control group (16.1 x 12.7 mM/L). Furthermore, the Pdmax of the deficient group was lower than that of the control group (12.5 x 19.4 mV). The results showed that in niacin deficiency occurs a decreasing of the active electrogenic glucose absorption. One of the possible interpretation of the differences in the kinetic characteristics of electrogenic glucose transport would be a depleted energy supplement for the active transport in the enterocyte of the niacin deficient rats.
dc.languagepor
dc.relationArquivos de Gastroenterologia
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdrug derivative
dc.subjectglucose
dc.subjectnicotinamide
dc.subjectnicotinic acid
dc.subjectactive transport
dc.subjectanimal
dc.subjectintestine absorption
dc.subjectjejunum
dc.subjectmale
dc.subjectmetabolism
dc.subjectnutritional deficiency
dc.subjectrat
dc.subjectrat strain
dc.subjecturine
dc.subjectAnimal
dc.subjectBiological Transport, Active
dc.subjectEnglish Abstract
dc.subjectGlucose
dc.subjectIntestinal Absorption
dc.subjectJejunum
dc.subjectMale
dc.subjectNiacin
dc.subjectNiacinamide
dc.subjectRats
dc.subjectRats, Wistar
dc.titleTransporte jejunal eletrogênico da glicose em ratos com deficiência de niacina.
dc.typeOtro


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