Oral bacille calmette-guérin (BCG) vaccination induces long-term potentiation of memory immune response to ovalbumin airway challenge in mice

dc.creatorHammes, Andreza
dc.creatorCardillo, Fabíola
dc.creatorFrota, Rodolfo
dc.creatorPinho, Rosa Teixeira de
dc.creatorMengel, José
dc.date2022-12-22T11:46:29Z
dc.date2022-12-22T11:46:29Z
dc.date2022
dc.date.accessioned2023-09-26T20:44:16Z
dc.date.available2023-09-26T20:44:16Z
dc.identifierHAMMES, Andreza et al. Oral Bacille Calmette-Guérin (BCG) vaccination induces long-term potentiation of memory immune response to Ovalbumin airway challenge in mice. Immunology Letters, v. 249, p. 1-10, 2022.
dc.identifier0165-2478
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56152
dc.identifier10.1016/j.imlet.2022.08.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862958
dc.descriptionFundação Oswaldo Cruz (FIOCRUZ ) Fundação Octacílio Gualberto (FOG).
dc.descriptionThe Bacille Calmette-Gu´erin (BCG) is a potent immunomodulator. It was initially used by oral administration, but it is mostly used subcutaneously nowadays. This study shows that oral BCG vaccination modifies the immune response to a second non-related antigen (Ovalbumin) systemic immunization. Airway Ovalbumin challenge six months after the systemic intraperitoneal immunization resulted in a potent γδ+ T cell response in the lungs biased to IFN-γ and IL-17 production ex vivo and a mixed TH1, TH2, and TH17 T cells upon further stimulation with anti-CD3 mAb in vitro. Higher percentages of CD4+ T cells accompanied the augmented T cell response in oral BCG vaccinated mice. Also, the proportion of Foxp3+ Tregs was diminished compared to PBS-gavaged and OVA-immunized mice. The anti-OVA-specific antibody response was also influenced by oral exposure to BCG so that these mice produced more IgG2a and less IgE detected in the sera. These results suggest that oral BCG vaccination can modify future immune responses to vaccines and improve immunity to pathogen infections, especially in the mucosal interfaces.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherElsevier
dc.rightsopen access
dc.subjectBCG
dc.subjectImunidade treinada
dc.subjectIFN-γ
dc.subjectTregs
dc.subjectFoxp3
dc.subjectCélulas T γδ
dc.subjectBCG
dc.subjectTrained immunity
dc.subjectIFN-γ
dc.subjectTregs
dc.subjectFoxp3
dc.subjectγδ T cells
dc.subjectImunidade
dc.titleOral bacille calmette-guérin (BCG) vaccination induces long-term potentiation of memory immune response to ovalbumin airway challenge in mice
dc.typeArticle


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