Yield of Repeat Tuberculin Skin Testing for People Living With HIV in Brazil

dc.creatorChaisson, Lelia H.
dc.creatorSaraceni, Valeria
dc.creatorCohn, Silvia
dc.creatorCavalcante, Solange C.
dc.creatorChaisson, Richard E.
dc.creatorDurovni, Betina
dc.creatorGolub, Jonathan E.
dc.date2022-07-15T10:39:43Z
dc.date2022-07-15T10:39:43Z
dc.date2021
dc.date.accessioned2023-09-26T20:44:13Z
dc.date.available2023-09-26T20:44:13Z
dc.identifierCHAISSON, Lelia H. et al. Brief Report: Yield of Repeat Tuberculin Skin Testing for People Living With HIV in Brazil. Journal of acquired immune deficiency syndromes, v. 88, n. 4, p. 329-332, 2021.
dc.identifier1525-4135
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53818
dc.identifier10.1097/QAI.0000000000002779
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862942
dc.descriptionObjectives: In Brazil, annual tuberculin skin tests (TSTs) are recommended for people living with HIV (PLWH) with CD4 >350, with tuberculosis preventive therapy provided on test conversion. We aimed to determine the yield of repeat TSTs for PLWH. Design: Secondary analysis of the stepped-wedge, cluster-randomized THRio trial for isoniazid preventive therapy (IPT) to prevent tuberculosis (TB). Methods: We analyzed data from newly registered PLWH with negative baseline TST results. We calculated the number of TST conversions after 1 and/or 2 years among patients eligible for follow-up TSTs, the proportion of converters initiating IPT, and incidence of TB/death. Results: Among 1770 PLWH with a negative baseline TST, 679 (38%) were female and median age was 36 years (IQR 29-43). Eighty-six (5%) developed TB or died within 1 year. Among 1684 eligible for a follow-up 1-year TST, 582 (35%) were tested and 53 (9%) were positive. Forty-nine converters (92%) started IPT. Of 529 patients with a negative 1-year TST, 7 (1%) developed TB or died over the following year. Of 522 patients eligible for a 2-year TST, 158 (30%) were tested and 13 (8%) were positive. Ten converters (77%) started IPT. Of 1102 patients who did not receive a 1-year TST, 33 (3%) developed TB or died. Of the 1069 patients eligible for a 2-year TST, 259 (24%) were tested and 34 (13%) were positive. Thirty converters (88%) started IPT. Conclusions: In this cohort of PLWH in Brazil, TST conversion was high among those retested, but only 48% received a follow-up TST within 2 years.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWolters Kluwer
dc.rightsrestricted access
dc.subjectTuberculosis
dc.subjectTuberculin skin test
dc.subjectLTBI
dc.subjectHIV
dc.titleYield of Repeat Tuberculin Skin Testing for People Living With HIV in Brazil
dc.typeArticle


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