Comparative mechanical study of isolated papillary muscle from Wistar-Kyoto and Wistar rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorOkoshi, Marina Politi
dc.creatorPadovani, Carlos Roberto
dc.creatorNardi, S. C.
dc.creatorCicogna, Antonio Carlos
dc.date2014-05-27T11:17:55Z
dc.date2016-10-25T18:13:16Z
dc.date2014-05-27T11:17:55Z
dc.date2016-10-25T18:13:16Z
dc.date1994-01-01
dc.date.accessioned2017-04-06T00:45:06Z
dc.date.available2017-04-06T00:45:06Z
dc.identifierJapanese Heart Journal, v. 35, n. 3, p. 333-343, 1994.
dc.identifier0021-4868
dc.identifierhttp://hdl.handle.net/11449/64446
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64446
dc.identifier10.1536/ihj.35.333
dc.identifier2-s2.0-0028108460.pdf
dc.identifier2-s2.0-0028108460
dc.identifierhttp://dx.doi.org/10.1536/ihj.35.333
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886293
dc.descriptionIsolated papillary muscles have often been used in myocardial mechanical function studies. The objective of the present study was to compare the mechanical function of papillary muscle isolated from left ventricle between Wistar (W) and Wistar-Kyoto (WKY) rats of different ages (1, 3, 6 and 12 months), in order to examine whether there is a difference in intrinsic mechanical properties of muscle between the two rat strains. Muscles were perfused with Krebs-Henseleit solution at 28°C and studied isometrically and isotonically at a stimulation rate of 0.2 Hz. The W and WKY showed statistically significant differences during both isometric and isotonic contractions. During isometric contraction? (l) the peak developed tension (DT) and + dT/dt were lower in WKY rats in the 1 mo groups, (2) the resting tension (RT) was greater in WKY at 3, 6 and 12 mo. (3) time to peak tension (TPT) was greater in WKY at 3 and 12 mo, (4) time for tension to fall from peak to 50% of peak tension (RT 1/2) was greater in WKY at 3 mo and (5) - dT/dt was lower in WKY at 1 and 3 mo. During isotonic contraction, (1) the peak shortening (PS) and -dL/dt were lower in WKY at 12 mo, (2) the time to peak shortening (TPS) was greater in WKY at 3 and 12 mo; (3) + dL/dt was lower in WKY at 3, 6, and 12 mo and (4) the relative variation of length (Lmax-PS)/Lmax was greater in WKY at 6 and 12 mo. These data showed a difference in mechanical behaviour of the papillary muscle between Wistar and Wistar-Kyoto rats of different age.
dc.languageeng
dc.relationJapanese Heart Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiac muscle function
dc.subjectIsolated papillary muscles
dc.subjectWistar rats
dc.subjectWistar-Kyoto rats
dc.subjectage
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcomparative study
dc.subjectheart function
dc.subjectheart left ventricle
dc.subjectheart papillary muscle
dc.subjectmale
dc.subjectmechanics
dc.subjectmuscle isometric contraction
dc.subjectmuscle isotonic contraction
dc.subjectmuscle tone
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAging
dc.subjectAnimal
dc.subjectComparative Study
dc.subjectIn Vitro
dc.subjectIsometric Contraction
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectOrgan Weight
dc.subjectPapillary Muscles
dc.subjectRats
dc.subjectRats, Inbred WKY
dc.subjectRats, Wistar
dc.subjectSupport, Non-U.S. Gov't
dc.titleComparative mechanical study of isolated papillary muscle from Wistar-Kyoto and Wistar rats
dc.typeOtro


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