First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil

dc.creatorOliveira, Rômulo Vieira Mello de
dc.creatorCorrêa-Moreira, Danielly
dc.creatorMendes, Túlio Vieira
dc.creatorCosta, Gisela Lara da
dc.creatorVieira, Renata de Magalhães
dc.creatorBuchele, Cynthia Miranda Nascimento
dc.creatorLins, Rodrigo Schrage
dc.creatorFerreira, Ana Beatriz Teixeira Brandão Camello
dc.creatorVeira, Daniela Barbosa
dc.creatorPedroso, Rafael Santos de Aragão
dc.creatorFaria, Vinícius Tadeu Dias Pereira de
dc.creatorOliveira, Manoel Marques Evangelista
dc.date2023-01-06T12:41:42Z
dc.date2023-01-06T12:41:42Z
dc.date2023
dc.date.accessioned2023-09-26T20:44:00Z
dc.date.available2023-09-26T20:44:00Z
dc.identifierOLIVEIRA, Rômulo Vieira Mello de et al. First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil. International Journal of Infectious Diseases, v. 126, p. 94-97, Jan. 2023.
dc.identifier1201-9712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56345
dc.identifier10.1016/j.ijid.2022.11.015
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862876
dc.descriptionIntroduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. Objectives: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. Methods: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and β-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. Conclusion: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Open Access
dc.rightsopen access
dc.subjectInfeções fungais
dc.subjectPaciente imunocompetente
dc.subjectMeningoencefalite
dc.subjectPenicillium
dc.subjectPenicillium chrysogenum
dc.subjectFungal infections
dc.subjectImmunocompetent patient
dc.subjectMeningoencephalitis
dc.subjectPenicillium
dc.subjectPenicillium chrysogenum
dc.titleFirst report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
dc.typeArticle


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