Corynebacterium ulcerans isolates from humans and dogs: fibrinogen, fibronectin and collagen-binding, antimicrobial and PFGE profiles

dc.creatorLouredo, Liliane Simpson
dc.creatorRamos, Juliana Nunes
dc.creatorPeixoto, Renta Stavracakis
dc.creatorSantos, Louisy Sanches
dc.creatorAntunes, Camila Azevedo
dc.creatorLadeira, Elisa Martins
dc.creatorSantos, Cintia Silva
dc.creatorVieira, Veronica Viana
dc.creatorVillas Bôas, Maria Helena Simões
dc.creatorHirata Jr., Raphael
dc.creatorGuaraldi, Ana Luiza Mattos
dc.date2015-05-19T13:26:09Z
dc.date2015-05-19T13:26:09Z
dc.date2014
dc.date.accessioned2023-09-26T20:43:57Z
dc.date.available2023-09-26T20:43:57Z
dc.identifierLOUREDO, Liliane Simpson et al. Corynebacterium ulcerans isolates from humans and dogs: fibrinogen, fibronectin and collagen-binding, antimicrobial and PFGE profiles. Antonie van Leeuwenhoek, v.105, n.2, p 343-352, 2014.
dc.identifier1572-9699
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10414
dc.identifier10.1007/s10482-013-0080-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862861
dc.descriptionCorynebacterium ulcerans has been increasingly isolated as an emerging zoonotic agent of diphtheria and other infections from companion animals. Since pets are able to act as symptomless carriers, it is also essential to identify virulence potential for humans of these isolates. In this work the ability of C. ulcerans to bind to fibrinogen (Fbg), fibronectin (Fn) and Type I collagen as well the genetic relationship among strains isolated from human and asymptomatic dogs in Rio de Janeiro (Brazil) were analyzed. Five pulsed-field gel electrophoresis (PFGE) profiles were demonstrated (I, II, III, IV and V). In addition, the IV and V profiles exhibiting ≥85 % similarity were expressed by the BR-AD41 and BR-AD61 strains from companion dogs living in the same neighborhood. Independent of the PFGE-types, human and dog isolates showed affinity to Fbg, Fn and collagen. Heterogeneity of PFGE profiles indicated endemicity of C. ulcerans in the Rio de Janeiro metropolitan area. Differences in the expression of adhesins to the human extracellular matrix may contribute to variations in the virulence and zoonotic potential of C. ulcerans strains.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectCorynebacterium ulcerans
dc.subjectFibrinogen
dc.subjectFibrincetin
dc.subjectFibronectin
dc.subjectPFGE
dc.subjectFibrinógeno
dc.subjectFibronectinas
dc.subjectFibrinogênio
dc.subjectFibronectinas
dc.titleCorynebacterium ulcerans isolates from humans and dogs: fibrinogen, fibronectin and collagen-binding, antimicrobial and PFGE profiles
dc.typeArticle


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